Literature DB >> 2575588

A multipoint linkage map around the locus for myotonic dystrophy on chromosome 19.

H G Brunner1, H Smeets, H M Lambermon, M Coerwinkel-Driessen, B A van Oost, B Wieringa, H H Ropers.   

Abstract

Employing 16 polymorphic DNA markers as well as the chromosome 19 centromere heteromorphism, we have performed a genetic linkage study in 26 families with myotonic dystrophy. Fourteen of these markers had been assigned previously to one of five different intervals of the 19cen-19q13.2 segment by using somatic cell hybrids. For the long arm of chromosome 19, a genetic map that encompasses 9 polymorphic markers and the DM gene has been constructed. Our studies indicate that the DM and CKMM genes map distal to the ApoC2-ApoE gene cluster and to the anonymous polymorphic markers D19S15 and D19S16, but proximal to the D19S22 marker. The orientation of DM and CKMM remains to be determined.

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Year:  1989        PMID： 2575588     DOI： 10.1016/0888-7543(89)90027-x

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  19 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  Foveal photopigment kinetics--abnormality: an early sign in myotonic dystrophy?

Authors:  J P ter Bruggen; G J van Meel; A D Paridaens; C C Tijssen; D van Norren
Journal:  Br J Ophthalmol       Date:  1992-10       Impact factor: 4.638

3.  The physical map of chromosome arm 19q: some new assignments, confirmations and re-assessments.

Authors:  J D Brook; S J Knight; S H Roberts; H G Harley; K V Walsh; S A Rundle; K Freyne; M C Koch; N D Epstein; B Wieringa
Journal:  Hum Genet       Date:  1991-05       Impact factor: 4.132

4.  Localisation of the myotonic dystrophy locus to 19q13.2-19q13.3 and its relationship to twelve polymorphic loci on 19q.

Authors:  H G Harley; K V Walsh; S Rundle; J D Brook; M Sarfarazi; M C Koch; J L Floyd; P S Harper; D J Shaw
Journal:  Hum Genet       Date:  1991-05       Impact factor: 4.132

5.  Diagnosis of susceptibility to malignant hyperthermia with flanking DNA markers.

Authors:  S J Healy; J J Heffron; M Lehane; D G Bradley; K Johnson; T V McCarthy
Journal:  BMJ       Date:  1991-11-16

Review 6.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

7.  Evidence for genetic heterogeneity of malignant hyperthermia susceptibility.

Authors:  T Deufel; A Golla; D Iles; A Meindl; T Meitinger; D Schindelhauer; A DeVries; D Pongratz; D H MacLennan; K J Johnson
Journal:  Am J Hum Genet       Date:  1992-06       Impact factor: 11.025

8.  Use of variable simple sequence motifs as genetic markers: application to study of myotonic dystrophy.

Authors:  H J Smeets; H G Brunner; H H Ropers; B Wieringa
Journal:  Hum Genet       Date:  1989-10       Impact factor: 4.132

9.  Identification of new DNA markers close to the myotonic dystrophy locus.

Authors:  J D Brook; H G Harley; K V Walsh; S A Rundle; M J Siciliano; P S Harper; D J Shaw
Journal:  J Med Genet       Date:  1991-02       Impact factor: 6.318

10.  D19S51 is closely linked with and maps distal to the myotonic dystrophy locus on 19q.

Authors:  C Tsilfidis; A E MacKenzie; G Shutler; S Leblond; J Bailly; K Johnson; R Williamson; J Siegel-Bartelt; R G Korneluk; P Shelbourne
Journal:  Am J Hum Genet       Date:  1991-11       Impact factor: 11.025
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