Qingxi Meng1, Xiaojun Zhang1, Xin Liu1, Weiguo Wang1, Peng Yu2, Qunqun Shan1, Zhaohu Mao1, Tingbao Zhao1. 1. Department of Spinal Cord Injury, Institute of Orthopedics and Traumatology of Chinese PLA, General Hospital of Jinan Military Area Command Jinan, Shandong, China. 2. The First Veteran Institute of Jinan Military Region Jinan, Shandong, China.
Abstract
BACKGROUND: As a susceptibility gene for AS, the polymorphsims of PTPN22 associated with disease susceptibility. METHODS: We selected two SNPs of rs1217406 and rs1217414 within PTPN22 with Haploview software and investigated the relationship between the SNPs of PTPN22 gene and AS susceptibility. 120 AS patients and 100 healthy people were enrolled from Qilu Hospital of Shandong University. And we genotyped the SNPs of PTPN22 with PCR-RFLP method. RESULTS: The results showed that C allele (rs1217406) and T allele (rs1217414) both were risk factors for AS (OR: 3.12, 2.13). The persons with A-T, C-C or C-T haplotypes were more likely to suffer AS (OR: 3.17, 3.66, 4.011). CONCLUSIONS: Due to the close relationship of PTPN22 and AS, the study may be helpful for the early diagnosis and differential diagnosis.
BACKGROUND:As a susceptibility gene for AS, the polymorphsims of PTPN22 associated with disease susceptibility. METHODS: We selected two SNPs of rs1217406 and rs1217414 within PTPN22 with Haploview software and investigated the relationship between the SNPs of PTPN22 gene and AS susceptibility. 120 ASpatients and 100 healthy people were enrolled from Qilu Hospital of Shandong University. And we genotyped the SNPs of PTPN22 with PCR-RFLP method. RESULTS: The results showed that C allele (rs1217406) and T allele (rs1217414) both were risk factors for AS (OR: 3.12, 2.13). The persons with A-T, C-C or C-T haplotypes were more likely to suffer AS (OR: 3.17, 3.66, 4.011). CONCLUSIONS: Due to the close relationship of PTPN22 and AS, the study may be helpful for the early diagnosis and differential diagnosis.
Authors: Victoria E H Carlton; Xiaolan Hu; Anand P Chokkalingam; Steven J Schrodi; Rhonda Brandon; Heather C Alexander; Monica Chang; Joseph J Catanese; Diane U Leong; Kristin G Ardlie; Daniel L Kastner; Michael F Seldin; Lindsey A Criswell; Peter K Gregersen; Ellen Beasley; Glenys Thomson; Christopher I Amos; Ann B Begovich Journal: Am J Hum Genet Date: 2005-08-10 Impact factor: 11.025
Authors: Ann B Begovich; Victoria E H Carlton; Lee A Honigberg; Steven J Schrodi; Anand P Chokkalingam; Heather C Alexander; Kristin G Ardlie; Qiqing Huang; Ashley M Smith; Jill M Spoerke; Marion T Conn; Monica Chang; Sheng-Yung P Chang; Randall K Saiki; Joseph J Catanese; Diane U Leong; Veronica E Garcia; Linda B McAllister; Douglas A Jeffery; Annette T Lee; Franak Batliwalla; Elaine Remmers; Lindsey A Criswell; Michael F Seldin; Daniel L Kastner; Christopher I Amos; John J Sninsky; Peter K Gregersen Journal: Am J Hum Genet Date: 2004-06-18 Impact factor: 11.025