Literature DB >> 25755750

Long noncoding RNA linc-UBC1 is negative prognostic factor and exhibits tumor pro-oncogenic activity in gastric cancer.

Yiren Hu1, Jianghua Pan1, Yi Wang1, Linjing Li1, Yi Huang1.   

Abstract

Despite the advances in the management of gastric cancer, the prognosis of advanced gastric cancer remains relatively poor. Thus, it is of urgent need to identify novel prognostic markers and therapeutic targets of gastric cancer. A growing volume of literature has indicated that lncRNAs are differentially expressed in a diverse array of cancer and play an important role in the development of cancer. Linc-UBC1, a recently identified long noncoding RNA, was initially found to be upregulated in bladder cancer. However, the role of linc-UBC1 in gastric cancer remains to be elusive. In this study, we found that linc-UBC1 was significantly upregulated in gastric cancer tissues compared to adjacent normal tissues. Furthermore, high linc-UBC1 expression was associated with lymph-node metastasis, tumor size, TNM stage and poorer prognosis. Inhibition of linc-UBC1 suppressed the proliferation, motility and invasion of gastric cancer cells. Our study suggests that linc-UBC1 may represent a novel diagnostic, prognostic biomarker and a potential therapeutic target of gastric cancer.

Entities:  

Keywords:  Gastric cancer; linc-UBC1; long noncoding RNA; prognosis

Mesh：

Substances：

Year:  2015        PMID： 25755750      PMCID： PMC4348840     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  19 in total

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  19 in total

Review 1.  Recent advances in the molecular diagnostics of gastric cancer.

Authors:  Mitsuro Kanda; Yasuhiro Kodera
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Journal:  Medicine (Baltimore)       Date:  2017-11       Impact factor: 1.889

8.  Bronchial Epithelial Cells from Cystic Fibrosis Patients Express a Specific Long Non-coding RNA Signature upon Pseudomonas aeruginosa Infection.

Authors:  Viviane Balloy; Remya Koshy; Lea Perra; Harriet Corvol; Michel Chignard; Loïc Guillot; Vinod Scaria
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9.  Overexpression of the long non-coding RNA, linc-UBC1, is associated with poor prognosis and facilitates cell proliferation, migration, and invasion in colorectal cancer.

Authors:  Xunfeng Gao; Jianfan Wen; Peng Gao; Guowei Zhang; Gangqing Zhang
Journal:  Onco Targets Ther       Date:  2017-02-22       Impact factor: 4.147

10.  Long noncoding RNA BLACAT1 promotes cell proliferation and invasion in human cervical cancer.

Authors:  Dan Shan; Yumin Shang; Tongxiu Hu
Journal:  Oncol Lett       Date:  2018-01-11       Impact factor: 2.967
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