| Literature DB >> 25754818 |
Dong Han1, Meng Wang2, Ning Ma3, Ya Xu3, Yuting Jiang3, Xu Gao4.
Abstract
Colorectal cancer (CRC) is the most common type of cancer in the world. Despite its commonness, the underlying mechanism of CRC is not completely understood. Long noncoding RNAs (lncRNAs) have received increased attention with the development of whole genome and transcriptome sequencing technologies. Recent findings reveal that lncRNAs are implicated in serial steps of cancer development. These lncRNAs interact with DNA, RNA, protein molecules and/or their combinations, acting as an essential regulator in chromatin organization, and transcriptional and post-transcriptional regulation. In this review, we highlight recent findings of emerging roles for lncRNAs in CRC and discuss rapid translational lncRNA research for clinical application in diagnosis, prognosis and potential treatment.Entities:
Keywords: Colorectal cancer (CRC); Long noncoding RNAs; Therapeutic targets; Tumorigenesis
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Year: 2015 PMID： 25754818 DOI： 10.1016/j.canlet.2015.03.002
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679