Literature DB >> 2575472

Increase of IgA-specific switch T cells in patients with IgA nephropathy.

H Sakai1, M Miyazaki, M Endoh, Y Nomoto.   

Abstract

Enumeration and functional analysis of CD4+ T cells with receptors for the Fc portion of IgA (i.e. T alpha 4 cells) in the peripheral blood of patients with IgA nephropathy, their relatives and age-matched controls were performed to elucidate polyclonal activation of IgA production in this disease. Enumeration of T alpha 4 cells was performed by a fluorescence activated cell sorter, and functional analysis was carried out by separation of T alpha 4 cells, and IgM-, IgA- and IgG-bearing lymphocytes using panning methods followed by cultures of these cells for 7 days with pokeweed mitogen. There was a significant increase in the amount of peripheral blood T alpha 4 cells in patients with IgA nephropathy and their relatives. T alpha 4 cells specifically enhanced the switch of IgM-bearing cells to IgA-bearing cells, and this switch activity was inhibited by addition of human myeloma IgA. It is suggested that T alpha 4 cells may be responsible for polyclonal activation of IgA production in IgA nephropathy.

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Year:  1989        PMID: 2575472      PMCID: PMC1534817     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN: 0009-9104            Impact factor:   4.330


  14 in total

1.  Decrease of IgA-specific suppressor T cell activity in patients with IgA nephropathy.

Authors:  H Sakai; Y Nomoto; S Arimori
Journal:  Clin Exp Immunol       Date:  1979-11       Impact factor: 4.330

2.  An extension of the 51Cr-release assay for the estimation of mouse cytotoxins.

Authors:  W Boyle
Journal:  Transplantation       Date:  1968-09       Impact factor: 4.939

Review 3.  A functional dichotomy in CD4+ T lymphocytes.

Authors:  K Bottomly
Journal:  Immunol Today       Date:  1988-09

4.  Isotype-specific suppression of IgA: suppression of IgA responses in BALB/c mice by T alpha cells.

Authors:  R G Hoover; R G Lynch
Journal:  J Immunol       Date:  1983-02       Impact factor: 5.422

5.  IgA-specific helper activity of T alpha cells in human peripheral blood.

Authors:  M Endoh; H Sakai; Y Nomoto; Y Tomino; H Kaneshige
Journal:  J Immunol       Date:  1981-12       Impact factor: 5.422

6.  T alpha cell subsets in human peripheral blood.

Authors:  T Suga; M Endoh; H Sakai; M Miura; Y Tomino; Y Nomoto
Journal:  J Immunol       Date:  1985-03       Impact factor: 5.422

7.  Altered expression of lymphocyte Fc alpha receptor in selective IgA deficiency and IgA nephropathy.

Authors:  M Adachi; J Yodoi; T Masuda; K Takatsuki; H Uchino
Journal:  J Immunol       Date:  1983-09       Impact factor: 5.422

8.  T cell hybridomas coexpressing Fc receptors (FcR) for different isotypes. II. IgA-induced formation of suppressive IgA binding factor(s) by a murine T hybridoma bearing Fc gamma R and Fc alpha R.

Authors:  J Yodoi; M Adachi; K Teshigawara; M Miyamainaba; T Masuda; W H Fridman
Journal:  J Immunol       Date:  1983-07       Impact factor: 5.422

9.  Increase of IgA specific helper T alpha cells in patients with IgA nephropathy.

Authors:  H Sakai; M Endoh; Y Tomino; Y Nomoto
Journal:  Clin Exp Immunol       Date:  1982-10       Impact factor: 4.330

10.  Murine Peyer's patch T cell clones. Characterization of antigen-specific helper T cells for immunoglobulin A responses.

Authors:  H Kiyono; J R McGhee; L M Mosteller; J H Eldridge; W J Koopman; J F Kearney; S M Michalek
Journal:  J Exp Med       Date:  1982-10-01       Impact factor: 14.307

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  7 in total

1.  Oligoclonally expanding gammadelta T lymphocytes induce IgA switching in IgA nephropathy.

Authors:  S Toyabe; W Harada; M Uchiyama
Journal:  Clin Exp Immunol       Date:  2001-04       Impact factor: 4.330

Review 2.  The structure and function of human IgA.

Authors:  M A Kerr
Journal:  Biochem J       Date:  1990-10-15       Impact factor: 3.857

3.  Transforming growth factor-beta in a model of IgA switching.

Authors:  D Y Kunimoto
Journal:  Immunol Res       Date:  1991       Impact factor: 2.829

4.  Monoclonal IgA gammopathy in a well infant.

Authors:  D E Campbell; A S Kemp
Journal:  Arch Dis Child       Date:  1996-01       Impact factor: 3.791

5.  Aberrant glycosylation of IgA from patients with IgA nephropathy.

Authors:  D Baharaki; M Dueymes; R Perrichot; C Basset; R Le Corre; J Clèdes; P Youinou
Journal:  Glycoconj J       Date:  1996-08       Impact factor: 2.916

Review 6.  Pathogenesis of idiopathic IgA nephropathy.

Authors:  D G Williams
Journal:  Pediatr Nephrol       Date:  1993-06       Impact factor: 3.714

7.  Increase of both circulating Th1 and Th2 T lymphocyte subsets in IgA nephropathy.

Authors:  K N Lai; R T Ho; C K Lai; C H Chan; P K Li
Journal:  Clin Exp Immunol       Date:  1994-04       Impact factor: 4.330

  7 in total

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