Anthony W H Chan1, Ronald C K Chan2, Grace L H Wong3,4, Vincent W S Wong3,4, Paul C L Choi1, Henry L Y Chan3,4, Ka-Fai To1,4,5. 1. Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China. 2. Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. 3. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. 4. Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China. 5. Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, China.
Abstract
BACKGROUND AND AIM: Serum albumin and bilirubin are the most significant independent prognostic factors to predict hepatic events in patients with primary biliary cirrhosis (PBC). We aimed to investigate the prognostic significance of a new prognostic score, the albumin-bilirubin (ALBI) score, among PBC patients. METHODS: In a retrospective longitudinal cohort of 61 Chinese PBC patients with follow-up period up to 18.3 years, the prognostic performance of the ALBI in prediction of hepatic events was compared with other well-established prognostic scores: Child-Pugh score, model of end-stage liver disease, Mayo risk score, Yale, European, and Newcastle models. RESULTS: Fifteen patients (24.6%) developed hepatic events during follow-up. The c-index (0.894) and χ(2) by likelihood ratio test (36.34) of the ALBI score were highest in comparison to other models. The ALBI score was the only independent prognostic factor by multivariate analysis and its adjusted hazard ratio of developing hepatic event was 27.8 (P < 0.001). There were three prognostically different groups stratified by the ALBI score: ALBI grade 1 (≤ -2.60), grade 2 (> -2.60 to -1.39), and grade 3 (> -1.39) groups. The 2-, 5-, and 10-year event-free survivals for grade 1, grade 2, and grade 3 groups were 100.0% versus 100.0% versus 57.1%, 100.0% versus 88.5% versus 14.3%, and 100.0% versus 81.7% versus 0.0%, respectively (P < 0.001). CONCLUSION: The ALBI score is readily derived from a blood test without using those factors evaluated subjectively or obtained by invasive procedures. It is an independent prognostic factor for PBC patients and provides better/similar prognostic performance compared with other prognostic scores.
BACKGROUND AND AIM: Serum albumin and bilirubin are the most significant independent prognostic factors to predict hepatic events in patients with primary biliary cirrhosis (PBC). We aimed to investigate the prognostic significance of a new prognostic score, the albumin-bilirubin (ALBI) score, among PBC patients. METHODS: In a retrospective longitudinal cohort of 61 Chinese PBC patients with follow-up period up to 18.3 years, the prognostic performance of the ALBI in prediction of hepatic events was compared with other well-established prognostic scores: Child-Pugh score, model of end-stage liver disease, Mayo risk score, Yale, European, and Newcastle models. RESULTS: Fifteen patients (24.6%) developed hepatic events during follow-up. The c-index (0.894) and χ(2) by likelihood ratio test (36.34) of the ALBI score were highest in comparison to other models. The ALBI score was the only independent prognostic factor by multivariate analysis and its adjusted hazard ratio of developing hepatic event was 27.8 (P < 0.001). There were three prognostically different groups stratified by the ALBI score: ALBI grade 1 (≤ -2.60), grade 2 (> -2.60 to -1.39), and grade 3 (> -1.39) groups. The 2-, 5-, and 10-year event-free survivals for grade 1, grade 2, and grade 3 groups were 100.0% versus 100.0% versus 57.1%, 100.0% versus 88.5% versus 14.3%, and 100.0% versus 81.7% versus 0.0%, respectively (P < 0.001). CONCLUSION: The ALBI score is readily derived from a blood test without using those factors evaluated subjectively or obtained by invasive procedures. It is an independent prognostic factor for PBC patients and provides better/similar prognostic performance compared with other prognostic scores.
Authors: R Diaz-Beveridge; G Bruixola; D Lorente; J Caballero; E Rodrigo; Á Segura; D Akhoundova; A Giménez; J Aparicio Journal: Clin Transl Oncol Date: 2017-08-11 Impact factor: 3.405
Authors: Nikolaos Andreatos; Neda Amini; Faiz Gani; Georgios A Margonis; Kazunari Sasaki; Vanessa M Thompson; David J Bentrem; Bruce L Hall; Henry A Pitt; Ana Wilson; Timothy M Pawlik Journal: J Gastrointest Surg Date: 2016-09-12 Impact factor: 3.452
Authors: Homan Mohammadi; Yazan Abuodeh; William Jin; Jessica Frakes; Mark Friedman; Benjamin Biebel; Junsung Choi; Ghassan El-Haddad; Bela Kis; Jennifer Sweeney; Sarah Hoffe Journal: J Gastrointest Oncol Date: 2018-10