L-L Quan1, H Wang, Y Tian, X Mu, Y Zhang, K Tao. 1. Department of Plastic Surgery, General Hospital of Shenyang Military Area Command, Shenhe District, Shenyang, Liaoning, China. kai-tao@tom.com.
Abstract
OBJECTIVE: To elucidate the association of fat-mass and obesity-associated gene (FTO) rs9939609 polymorphism with obesity among children and adolescents. METHODS: A literature search was conducted in PubMed, MEDLINE, Springer, and Google scholar to identify eligible studies. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used for four models: co-dominant model (AA vs. TT, AT vs. TT), dominant model (AA + AT vs. TT), recessive model (AA vs. AT + TT), and allelic model (A vs. T). Subgroup analyses stratified by ethnicity (Caucasian, others) and participants (children, children and adolescents) were assessed under allelic model. The heterogeneity and publication bias were examined. RESULTS: This meta-analysis included 12 eligible studies consisting 5,000 cases and 9,853 controls. The results revealed that FTO rs9939609 polymorphism was significantly associated with the increased risk of obesity in co-dominant model (AA vs. TT: OR = 1.91, 95% CI: 1.47-2.48, p < 0.01; AT vs. TT: OR = 1.18, 95% CI: 1.02-1.38, p = 0.03), dominant model (AA + AT vs. TT: OR = 1.47, 95% CI: 1.35-1.59, p < 0.01), recessive model (AA vs. AT + TT: OR = 1.79, 95% CI: 1.47-2.17, p < 0.01), and allelic model (A vs. T: OR = 1.39, 95% CI: 1.22-1.58, p < 0.01). Similar results were obtained for the subgroup analyses stratified by ethnicity and participants under allelic model. CONCLUSIONS: FTO rs9939609 polymorphism is associated with the increased risk of obesity among children and adolescents, especially the homozygous carriers.
OBJECTIVE: To elucidate the association of fat-mass and obesity-associated gene (FTO) rs9939609 polymorphism with obesity among children and adolescents. METHODS: A literature search was conducted in PubMed, MEDLINE, Springer, and Google scholar to identify eligible studies. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used for four models: co-dominant model (AA vs. TT, AT vs. TT), dominant model (AA + AT vs. TT), recessive model (AA vs. AT + TT), and allelic model (A vs. T). Subgroup analyses stratified by ethnicity (Caucasian, others) and participants (children, children and adolescents) were assessed under allelic model. The heterogeneity and publication bias were examined. RESULTS: This meta-analysis included 12 eligible studies consisting 5,000 cases and 9,853 controls. The results revealed that FTOrs9939609 polymorphism was significantly associated with the increased risk of obesity in co-dominant model (AA vs. TT: OR = 1.91, 95% CI: 1.47-2.48, p < 0.01; AT vs. TT: OR = 1.18, 95% CI: 1.02-1.38, p = 0.03), dominant model (AA + AT vs. TT: OR = 1.47, 95% CI: 1.35-1.59, p < 0.01), recessive model (AA vs. AT + TT: OR = 1.79, 95% CI: 1.47-2.17, p < 0.01), and allelic model (A vs. T: OR = 1.39, 95% CI: 1.22-1.58, p < 0.01). Similar results were obtained for the subgroup analyses stratified by ethnicity and participants under allelic model. CONCLUSIONS:FTOrs9939609 polymorphism is associated with the increased risk of obesity among children and adolescents, especially the homozygous carriers.
Authors: Éboni Marília Reuter; Cézane Priscila Reuter; João Francisco de Castro Silveira; Sean Carroll; James Philip Hobkirk; Pâmela Ferreira Todendi; Andréia Rosane de Moura Valim; Elza Daniel de Mello Journal: Eur J Pediatr Date: 2021-05-21 Impact factor: 3.183
Authors: Saad Mahmud Khan; Sarah El Hajj Chehadeh; Mehera Abdulrahman; Wael Osman; Habiba Al Safar Journal: BMC Med Genet Date: 2018-01-17 Impact factor: 2.103
Authors: Cézane P Reuter; Elza D de Mello; Priscila T da Silva; Tássia S Borges; Elisa I Klinger; Silvia I R Franke; Andréia R de M Valim Journal: J Obes Date: 2018-09-05