Jennifer K Frediani1, Ekaterina Sanikidze2, Maia Kipiani2, Nestani Tukvadze2, Gautam Hebbar3, Usha Ramakrishnan4, Dean P Jones5, Kirk A Easley6, Neeta Shenvi6, Russell R Kempker7, Vin Tangpricha1, Henry M Blumberg8, Thomas R Ziegler9. 1. Graduate Division of Biological and Biomedical Sciences, Nutrition and Health Sciences Graduate Program, Laney Graduate School, Emory University, Atlanta, GA 30322, United States; Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States; Center for Clinical and Molecular Nutrition, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States. 2. National Center for Tuberculosis and Lung Disease, Tbilisi, Georgia. 3. Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States; Center for Clinical and Molecular Nutrition, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States. 4. Graduate Division of Biological and Biomedical Sciences, Nutrition and Health Sciences Graduate Program, Laney Graduate School, Emory University, Atlanta, GA 30322, United States; Center for Clinical and Molecular Nutrition, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, United States. 5. Graduate Division of Biological and Biomedical Sciences, Nutrition and Health Sciences Graduate Program, Laney Graduate School, Emory University, Atlanta, GA 30322, United States; Center for Clinical and Molecular Nutrition, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States; Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States. 6. Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, United States. 7. Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States. 8. Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, United States; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States. 9. Graduate Division of Biological and Biomedical Sciences, Nutrition and Health Sciences Graduate Program, Laney Graduate School, Emory University, Atlanta, GA 30322, United States; Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States; Center for Clinical and Molecular Nutrition, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States. Electronic address: tzieg01@emory.edu.
Abstract
BACKGROUND: Malnutrition is common in patients with active tuberculosis (TB), yet little information is available on serial dietary intake or body composition in TB disease. OBJECTIVE: To evaluate macronutrient intake and body composition in individuals with newly diagnosed TB over time. DESIGN:Adults with active pulmonary TB (n = 191; 23 with multidrug resistant TB (MDR-TB) and 36 culture-negative household contacts (controls) enrolled in a clinical trial of high-dosecholecalciferol (vitamin D3) were studied. Macronutrient intake was determined at baseline, 8 and 16 weeks. Serial body composition was assessed by body mass index (BMI; kg/m(2)) and bioelectrical impedance analysis (BIA) to estimate fat mass and fat-free mass. Descriptive statistics, repeated measures ANOVA for changes over time and linear regression were used. RESULTS: At baseline, mean daily energy, protein, fat and carbohydrate (CHO) intakes were significantly higher, and body weight, BMI, fat-free mass and fat mass were significantly lower, between TB subjects and controls. These remained significant after adjusting for age, gender, employment status and smoking. In all TB subjects, baseline mean daily intakes of energy, fat and protein were adequate when compared to the US Dietary Reference Intakes and protein significantly increased over time (p < 0.0001). Body weight, BMI, and fat and fat-free mass increased over time. MDR-TB patients exhibited lower body weight and fat-free mass over time, despite similar daily intake of kcal, protein, and fat. CONCLUSIONS:Macronutrient intake was higher in TB patients than controls, but TB-induced wasting was evident. As macronutrient intake of TB subjects increased over time, there was a parallel increase in BMI, while body composition proportions were maintained. However, individuals with MDR-TB demonstrated concomitantly decreased body weight and fat-free mass over time versus drug-sensitive TB patients, despite increased macronutrient intake. Thus, MDR-TB appears to blunt anabolism to macronutrient intake, likely reflecting the catabolic effects of TB.
RCT Entities:
BACKGROUND:Malnutrition is common in patients with active tuberculosis (TB), yet little information is available on serial dietary intake or body composition in TB disease. OBJECTIVE: To evaluate macronutrient intake and body composition in individuals with newly diagnosed TB over time. DESIGN: Adults with active pulmonary TB (n = 191; 23 with multidrug resistant TB (MDR-TB) and 36 culture-negative household contacts (controls) enrolled in a clinical trial of high-dose cholecalciferol (vitamin D3) were studied. Macronutrient intake was determined at baseline, 8 and 16 weeks. Serial body composition was assessed by body mass index (BMI; kg/m(2)) and bioelectrical impedance analysis (BIA) to estimate fat mass and fat-free mass. Descriptive statistics, repeated measures ANOVA for changes over time and linear regression were used. RESULTS: At baseline, mean daily energy, protein, fat and carbohydrate (CHO) intakes were significantly higher, and body weight, BMI, fat-free mass and fat mass were significantly lower, between TB subjects and controls. These remained significant after adjusting for age, gender, employment status and smoking. In all TB subjects, baseline mean daily intakes of energy, fat and protein were adequate when compared to the US Dietary Reference Intakes and protein significantly increased over time (p < 0.0001). Body weight, BMI, and fat and fat-free mass increased over time. MDR-TB patients exhibited lower body weight and fat-free mass over time, despite similar daily intake of kcal, protein, and fat. CONCLUSIONS: Macronutrient intake was higher in TB patients than controls, but TB-induced wasting was evident. As macronutrient intake of TB subjects increased over time, there was a parallel increase in BMI, while body composition proportions were maintained. However, individuals with MDR-TB demonstrated concomitantly decreased body weight and fat-free mass over time versus drug-sensitive TB patients, despite increased macronutrient intake. Thus, MDR-TB appears to blunt anabolism to macronutrient intake, likely reflecting the catabolic effects of TB.
Authors: Adama Diallo; Désiré Lucien Dahourou; Ter Tiero Elias Dah; Souleymane Tassembedo; Romial Sawadogo; Nicolas Meda Journal: Pan Afr Med J Date: 2018-08-28
Authors: Gwenyth O Lee; Valerie A Paz-Soldan; Amy R Riley-Powell; Andrea Gómez; Carla Tarazona-Meza; Katerine Villaizan Paliza; Ramya Ambikapathi; Katherine Ortiz; German Comina; Gustavo Hernandez; Nehal Naik; Richard Oberhelman; Cesar Ugarte-Gil Journal: Curr Dev Nutr Date: 2020-01-03
Authors: João Paulo Silva de Paiva; Mônica Avelar Figueiredo Mafra Magalhães; Thiago Cavalcanti Leal; Leonardo Feitosa da Silva; Lucas Gomes da Silva; Rodrigo Feliciano do Carmo; Carlos Dornels Freire de Souza Journal: PLoS One Date: 2022-01-25 Impact factor: 3.240
Authors: Karim Damji; Ahmar H Hashmi; Lin Lin Kyi; Michele Vincenti-Delmas; Win Pa Pa Htun; Htet Ko Ko Aung; Tobias Brummaier; Chaisiri Angkurawaranon; Verena Carrara; Francois Nosten Journal: BMJ Open Date: 2022-01-07 Impact factor: 2.692
Authors: Moon-Kyung Shin; Ji Yeon Choi; Song Yee Kim; Eun Young Kim; Sang Hoon Lee; Kyung Soo Chung; Ji Ye Jung; Moo Suk Park; Young Sam Kim; Young Ae Kang Journal: Ther Adv Chronic Dis Date: 2021-11-18 Impact factor: 5.091