| Literature DB >> 25751816 |
Suchi Goel1, Mia Palmkvist1, Kirsten Moll1, Nicolas Joannin1, Patricia Lara2, Reetesh R Akhouri1, Nasim Moradi2, Karin Öjemalm2, Mattias Westman1, Davide Angeletti1, Hanna Kjellin3, Janne Lehtiö3, Ola Blixt4, Lars Ideström5, Carl G Gahmberg6, Jill R Storry7, Annika K Hult7, Martin L Olsson7, Gunnar von Heijne2, IngMarie Nilsson2, Mats Wahlgren1.
Abstract
Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), where they bind to RBCs--preferentially of blood group A--to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.Entities:
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Year: 2015 PMID： 25751816 DOI： 10.1038/nm.3812
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440