| Literature DB >> 32066522 |
Wenn-Chyau Lee1, Bruce Russell2, Radoslaw Mikolaj Sobota3,4, Khairunnisa Ghaffar1, Shanshan W Howland1, Zi Xin Wong1, Alexander G Maier5, Dominique Dorin-Semblat6,7, Subhra Biswas1, Benoit Gamain6,7, Yee-Ling Lau8, Benoit Malleret1,9, Cindy Chu10,11, François Nosten10,11, Laurent Renia1.
Abstract
In malaria, rosetting is described as a phenomenon where an infected erythrocyte (IRBC) is attached to uninfected erythrocytes (URBC). In some studies, rosetting has been associated with malaria pathogenesis. Here, we have identified a new type of rosetting. Using a step-by-step approach, we identified IGFBP7, a protein secreted by monocytes in response to parasite stimulation, as a rosette-stimulator for Plasmodium falciparum- and P. vivax-IRBC. IGFBP7-mediated rosette-stimulation was rapid yet reversible. Unlike type I rosetting that involves direct interaction of rosetting ligands on IRBC and receptors on URBC, the IGFBP7-mediated, type II rosetting requires two additional serum factors, namely von Willebrand factor and thrombospondin-1. These two factors interact with IGFBP7 to mediate rosette formation by the IRBC. Importantly, the IGFBP7-induced type II rosetting hampers phagocytosis of IRBC by host phagocytes.Entities:
Keywords: IGFBP7; P. falciparum; P. vivax; host-parasite interaction; immunology; infectious disease; inflammation; microbiology; phagocytosis; rosette
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Year: 2020 PMID： 32066522 PMCID： PMC7048393 DOI： 10.7554/eLife.51546
Source DB: PubMed Journal: Elife ISSN： 2050-084X Impact factor: 8.140