OBJECTIVE: The purpose of this study was to demonstrate the effect of low-level laser therapy (LLLT) on the peri-implant bone healing process in the rabbit mandible. BACKGROUND DATA: LLLT has been shown to accelerate tissue repair and osseointegration of implants placed into the rabbit tibia. However, the beneficial effects of LLLT have never been tested in the rabbit mandible, which would more closely mimic the human situation. MATERIALS AND METHODS: Twenty-four male New Zealand rabbits were randomly divided into four groups of six animals each. All animals had their left mandibular incisors extracted, followed by immediate insertion of a titanium dental implant in the fresh socket. Three groups received LLLT [aluminum-gallium-arsenide (AlGaAs), λ=830nm, 50 mW, continuous wave (CW)] at three different energy densities per treatment session (E-5, 5 J/cm(2); E-10, 10 J/cm(2); and E-20, 20 J/cm(2)). Irradiation was performed every 48 h for 13 days, totaling seven sessions. One group received sham treatment (controls). Histological sections were obtained from each of the 24 mandibles dissected, without first decalcifying the specimens, and were stained with hematoxylin and eosin and Picrosirius red for histomorphometric evaluation. Bone-to-implant contact (BIC), bone formation area, and collagen fiber area were assessed by light microscopy. RESULTS: Significant differences were found between group E-20 and all other groups (p<0.05). Histomorphometric evaluation showed significantly higher BIC and significantly more collagen fibers in group E-20. CONCLUSIONS: Photobiostimulation with LLLT at an energy density of 20 J/cm(2) per session had a significant positive effect on new bone formation around dental implants inserted in the rabbit mandible.
OBJECTIVE: The purpose of this study was to demonstrate the effect of low-level laser therapy (LLLT) on the peri-implant bone healing process in the rabbit mandible. BACKGROUND DATA: LLLT has been shown to accelerate tissue repair and osseointegration of implants placed into the rabbit tibia. However, the beneficial effects of LLLT have never been tested in the rabbit mandible, which would more closely mimic the human situation. MATERIALS AND METHODS: Twenty-four male New Zealand rabbits were randomly divided into four groups of six animals each. All animals had their left mandibular incisors extracted, followed by immediate insertion of a titanium dental implant in the fresh socket. Three groups received LLLT [aluminum-gallium-arsenide (AlGaAs), λ=830nm, 50 mW, continuous wave (CW)] at three different energy densities per treatment session (E-5, 5 J/cm(2); E-10, 10 J/cm(2); and E-20, 20 J/cm(2)). Irradiation was performed every 48 h for 13 days, totaling seven sessions. One group received sham treatment (controls). Histological sections were obtained from each of the 24 mandibles dissected, without first decalcifying the specimens, and were stained with hematoxylin and eosin and Picrosirius red for histomorphometric evaluation. Bone-to-implant contact (BIC), bone formation area, and collagen fiber area were assessed by light microscopy. RESULTS: Significant differences were found between group E-20 and all other groups (p<0.05). Histomorphometric evaluation showed significantly higher BIC and significantly more collagen fibers in group E-20. CONCLUSIONS: Photobiostimulation with LLLT at an energy density of 20 J/cm(2) per session had a significant positive effect on new bone formation around dental implants inserted in the rabbit mandible.
Authors: João Batista B Weber; Antonio Luiz B Pinheiro; Marília G de Oliveira; Flávio Augusto M Oliveira; Luciana Maria P Ramalho Journal: Photomed Laser Surg Date: 2006-02 Impact factor: 2.796
Authors: Alice Dias Petri; Lucas Novaes Teixeira; Grasiele Edilaine Crippa; Marcio Mateus Beloti; Paulo Tambasco de Oliveira; Adalberto Luiz Rosa Journal: Braz Dent J Date: 2010
Authors: Joelle Marie García-Morales; Pedro Tortamano-Neto; Francisco Fernando Todescan; José Carlos Silva de Andrade; Juliana Marotti; Denise Maria Zezell Journal: Lasers Med Sci Date: 2011-07-06 Impact factor: 3.161
Authors: Antonio Luiz Barbos Pinheiro; Francisco De Assis Limeira Júnior; Marleny Elizabeth Márquez Gerbi; Luciana Maria Pedreira Ramalho; Clovis Marzola; Elizabeth Arruda Carneiro Ponzi; André Oliveira Soares; Livia Cristina Bandeira De Carvalho; Helena Cristina Vieira Lima; Thais Oliveira Gonçalves Journal: J Clin Laser Med Surg Date: 2003-12
Authors: Alexandre Greca Diamantino; Renata Amadei Nicolau; Davidson Ribeiro Costa; Alessandra Paes de Barros Almeida; Danila Xênia de Miranda Mato; Marco Antonio de Oliveira; Ana Maria do Espírito Santo Journal: Lasers Med Sci Date: 2017-04-20 Impact factor: 3.161
Authors: Luciano Mayer; Fernando Vacilotto Gomes; Marília Gerhardt de Oliveira; João Feliz Duarte de Moraes; Lennart Carlsson Journal: Lasers Med Sci Date: 2016-08-17 Impact factor: 3.161
Authors: Mohammed A Hadis; Siti A Zainal; Michelle J Holder; James D Carroll; Paul R Cooper; Michael R Milward; William M Palin Journal: Lasers Med Sci Date: 2016-03-10 Impact factor: 3.161