Simon J Carrivick1, John P Walsh, Suzanne J Brown, Robert Wardrop, Narelle C Hadlow. 1. Department of Clinical Biochemistry (S.J.C., R.W., N.C.H.), PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia; Department of Endocrinology and Diabetes (S.J.C., J.P.W., S.J.B.), Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia; and School of Medicine and Pharmacology (J.P.W.) and School of Pathology and Laboratory Medicine (N.C.H.), The University of Western Australia, Crawley, Western Australia 6009, Australia.
Abstract
CONTEXT: Circulating PTH concentrations increase with age. It is uncertain whether an age-related PTH increase occurs independent of changes in circulating 25-hydroxyvitamin D, phosphate, renal function, and ionized calcium. OBJECTIVE: The purpose of this article was to analyze the relationship between PTH and age, controlling for 25-hydroxyvitamin D, phosphate, renal function, and ionized calcium. METHODS: This was a retrospective, cross-sectional study analyzing the relationship between PTH and age in 2 independent datasets (laboratory 1, n = 17 275 and laboratory 2, n = 4878). We further analyzed subgroups after excluding participants with estimated glomerular filtration rate of <60 mL/min/1.73 m(2) or 25-hydroxyvitamin D of <50 nmol/L (for subgroups, n = 12 051 for laboratory 1 and 3473 for laboratory 2). RESULTS: After adjustment for sex, ionized calcium, 25-hydroxyvitamin D, phosphate, and estimated glomerular filtration rate, each 10-year increase in age was associated with a 5.0% increase in PTH (95% confidence interval [CI], 4.4%-5.6%; P < .001) in laboratory 1 and a 4.2% increase in laboratory 2 (95% CI, 3.0%-5.4%; P < .001). In the subgroups, each 10-year increase in age was associated with a 6.1% increase in PTH (95% CI, 5.5%-6.8%; P < .001) in laboratory 1 and a 4.9% increase (95% CI 3.5%-6.2%; P < .001) in laboratory 2. CONCLUSION: PTH concentrations increase with age, independent of 25-hydroxyvitamin D, ionized calcium, phosphate, and renal function. Further research is required to explore the underlying mechanisms and clinical relevance and to determine whether the use of age-related PTH reference ranges improves diagnostic accuracy, particularly in elderly individuals.
CONTEXT: Circulating PTH concentrations increase with age. It is uncertain whether an age-related PTH increase occurs independent of changes in circulating 25-hydroxyvitamin D, phosphate, renal function, and ionizedcalcium. OBJECTIVE: The purpose of this article was to analyze the relationship between PTH and age, controlling for 25-hydroxyvitamin D, phosphate, renal function, and ionizedcalcium. METHODS: This was a retrospective, cross-sectional study analyzing the relationship between PTH and age in 2 independent datasets (laboratory 1, n = 17 275 and laboratory 2, n = 4878). We further analyzed subgroups after excluding participants with estimated glomerular filtration rate of <60 mL/min/1.73 m(2) or 25-hydroxyvitamin D of <50 nmol/L (for subgroups, n = 12 051 for laboratory 1 and 3473 for laboratory 2). RESULTS: After adjustment for sex, ionizedcalcium, 25-hydroxyvitamin D, phosphate, and estimated glomerular filtration rate, each 10-year increase in age was associated with a 5.0% increase in PTH (95% confidence interval [CI], 4.4%-5.6%; P < .001) in laboratory 1 and a 4.2% increase in laboratory 2 (95% CI, 3.0%-5.4%; P < .001). In the subgroups, each 10-year increase in age was associated with a 6.1% increase in PTH (95% CI, 5.5%-6.8%; P < .001) in laboratory 1 and a 4.9% increase (95% CI 3.5%-6.2%; P < .001) in laboratory 2. CONCLUSION:PTH concentrations increase with age, independent of 25-hydroxyvitamin D, ionizedcalcium, phosphate, and renal function. Further research is required to explore the underlying mechanisms and clinical relevance and to determine whether the use of age-related PTH reference ranges improves diagnostic accuracy, particularly in elderly individuals.
Authors: Annewieke W van den Beld; Jean-Marc Kaufman; M Carola Zillikens; Steven W J Lamberts; Josephine M Egan; Aart J van der Lely Journal: Lancet Diabetes Endocrinol Date: 2018-07-17 Impact factor: 32.069
Authors: Laura M G Meems; Frank P Brouwers; Michel M Joosten; Hiddo J Lambers Heerspink; Dick de Zeeuw; Stephan J L Bakker; Ron T Gansevoort; Wiek H van Gilst; Pim van der Harst; Rudolf A de Boer Journal: ESC Heart Fail Date: 2016-04-26
Authors: Chin Yi Chan; Shaanthana Subramaniam; Norazlina Mohamed; Soelaiman Ima-Nirwana; Norliza Muhammad; Ahmad Fairus; Pei Yuen Ng; Nor Aini Jamil; Noorazah Abd Aziz; Kok-Yong Chin Journal: Int J Environ Res Public Health Date: 2020-01-07 Impact factor: 3.390