| Literature DB >> 25750853 |
Scott M Hayes1, Michael L Alosco2, Daniel E Forman3.
Abstract
Aging is characterized by a decline in cognitive functions, particularly in the domains of executive function, processing speed and episodic memory. These age-related declines are exacerbated by cardiovascular disease (CVD) and cardiovascular risk factors (hypertension, diabetes, obesity, elevated total cholesterol). Structural and functional alterations in brain regions, including the fronto-parietal and medial temporal lobes, have been linked to age- and CVD-related cognitive decline. Multiple recent studies indicate that aerobic exercise programs may slow the progression of age-related neural changes and reduce the risk for mild cognitive impairment as well as dementia. We review age- and CVD-related decline in cognition and the underlying changes in brain morphology and function, and then clarify the impact of aerobic exercise on moderating these patterns.Entities:
Keywords: Aerobic fitness; Aging; Attention; Cardiorespiratory fitness; Cardiovascular disease; Cognitive control; Declarative memory; Diffusion tensor imaging; Episodic memory; Executive functions; Exercise; MRI; Memory; Physical activity; Processing speed; fMRI
Year: 2014 PMID： 25750853 PMCID： PMC4349343 DOI： 10.1007/s13670-014-0101-x
Source DB: PubMed Journal: Curr Geriatr Rep ISSN： 2196-7865