OBJECTIVES: To assess brain damage in Parkinson's disease (PD) based on apparent diffusion coefficient (ADC) data obtained from ultra-high b-values. METHODS: Eighteen PD patients and 18 controls received diffusion-weighted imaging (DWI) with standard b-values (0, 1,000 s/mm(2)) and 15 b-values (0-5,000 s/mm(2)). Standard ADC (ADCst) maps were calculated from standard b-values, while maps of pure diffusion coefficients (D), pseudo-diffusion coefficients (D(*)), and ultra-high ADCs (ADCuh) were calculated from the 15 b-values using a tri-component model. In this model, D and D(*) values were quantified with a bi-exponential equation using b-values less than 2,000 s/mm(2), while ADCuh was quantified by fitting the signals at ultra-high b-values (2,000-5,000 s/mm(2)) to the mono-exponential equation. ADCst, ADCuh, D, and D(*) of the globus pallidus (GP), putamen (P), and substantia nigra (SN) were compared between PD patients and normal control subjects. RESULTS: ADCuh of the GP, P, and SN was significantly lower in PD patients than those in control subjects (P < 0.001), while ADCst, D, and D(*) of the GP, P and SN were not different between the two groups (P > 0.05). CONCLUSIONS: ADCuh may be a useful measurement for evaluating brain damage in PD patients. KEY POINTS: • DWI with ultra-high b-values may provide new insight into Parkinson's disease pathology • ADC calculated using ultra-high b-values is different between PD and controls • ADC uh may be associated with water transportation by aquaporins.
OBJECTIVES: To assess brain damage in Parkinson's disease (PD) based on apparent diffusion coefficient (ADC) data obtained from ultra-high b-values. METHODS: Eighteen PDpatients and 18 controls received diffusion-weighted imaging (DWI) with standard b-values (0, 1,000 s/mm(2)) and 15 b-values (0-5,000 s/mm(2)). Standard ADC (ADCst) maps were calculated from standard b-values, while maps of pure diffusion coefficients (D), pseudo-diffusion coefficients (D(*)), and ultra-high ADCs (ADCuh) were calculated from the 15 b-values using a tri-component model. In this model, D and D(*) values were quantified with a bi-exponential equation using b-values less than 2,000 s/mm(2), while ADCuh was quantified by fitting the signals at ultra-high b-values (2,000-5,000 s/mm(2)) to the mono-exponential equation. ADCst, ADCuh, D, and D(*) of the globus pallidus (GP), putamen (P), and substantia nigra (SN) were compared between PDpatients and normal control subjects. RESULTS:ADCuh of the GP, P, and SN was significantly lower in PDpatients than those in control subjects (P < 0.001), while ADCst, D, and D(*) of the GP, P and SN were not different between the two groups (P > 0.05). CONCLUSIONS:ADCuh may be a useful measurement for evaluating brain damage in PDpatients. KEY POINTS: • DWI with ultra-high b-values may provide new insight into Parkinson's disease pathology • ADC calculated using ultra-high b-values is different between PD and controls • ADC uh may be associated with water transportation by aquaporins.
Authors: Hee Ho Chu; Seung Hong Choi; Inseon Ryoo; Soo Chin Kim; Jeong A Yeom; Hwaseon Shin; Seung Chai Jung; A Leum Lee; Tae Jin Yoon; Tae Min Kim; Se-Hoon Lee; Chul-Kee Park; Ji-Hoon Kim; Chul-Ho Sohn; Sung-Hye Park; Il Han Kim Journal: Radiology Date: 2013-10-28 Impact factor: 11.105
Authors: L-L Chan; H Rumpel; K Yap; E Lee; H-V Loo; G-L Ho; S Fook-Chong; Y Yuen; E-K Tan Journal: J Neurol Neurosurg Psychiatry Date: 2007-07-05 Impact factor: 10.154
Authors: Stefan T Schwarz; Maryam Abaei; Vamsi Gontu; Paul S Morgan; Nin Bajaj; Dorothee P Auer Journal: Neuroimage Clin Date: 2013-10-14 Impact factor: 4.881