Literature DB >> 2574671

Myocardial uptake of meta-[123I]-iodobenzylguanidine [( 123I]-MIBG) in patients with myocardial infarct.

D Fagret1, J E Wolf, M Comet.   

Abstract

Meta-123I-iodobenzylguanidine (123I-MIBG), which is an analog of norepinephrine, can be used to evaluate the integrity and function of sympathetic nerve endings in the heart. Myocardial uptake of 123I-MIBG was studied in 30 myocardial infarction patients and compared with the distribution of blood flow assessed with 201Tl. It was found that when a cold defect appeared on the 201Tl scintigram, its localization was identical to the cold defect on the 123I-MIBG scintigram. On the other hand, in three cases, a defect was found on the 123I-MIBG scintigram, corresponding to the electrocardiographic localization of the infarct, whereas the 201Tl scintigram was normal. Most strikingly, the present study shows that drugs (antagonists of the adrenergic receptors, calcium antagonists, amiodarone) decrease or even abolish (as in the case of labetalol) myocardial uptake of 123I-MIBG. Consequently, any interpretation of the 123I-MIBG scintigram must take into account the treatment administered.

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Year:  1989        PMID： 2574671     DOI： 10.1007/bf00256942

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  14 in total

1.  Metaiodobenzylguanidine [131I] scintigraphy detects impaired myocardial sympathetic neuronal transport function of canine mechanical-overload heart failure.

Authors:  M A Rabinovitch; C P Rose; J L Rouleau; C Chartrand; D M Wieland; L Lepanto; F Legault; S Suissa; L Rosenthall; J H Burgess
Journal:  Circ Res       Date:  1987-12       Impact factor: 17.367

2.  Inhibition of catecholamine uptake in the isolated rat heart by haloalkylamines related to phenoxybenzamine.

Authors:  L L Iversen; P J Salt; H A Wilson
Journal:  Br J Pharmacol       Date:  1972-12       Impact factor: 8.739

3.  Myocardial imaging with a radioiodinated norepinephrine storage analog.

Authors:  D M Wieland; L E Brown; W L Rogers; K C Worthington; J L Wu; N H Clinthorne; C A Otto; D P Swanson; W H Beierwaltes
Journal:  J Nucl Med       Date:  1981-01       Impact factor: 10.057

4.  Metaiodobenzylguanidine to map scintigraphically the adrenergic nervous system in man.

Authors:  J C Sisson; B Shapiro; L Meyers; S Mallette; T J Mangner; D M Wieland; J V Glowniak; P Sherman; W H Beierwaltes
Journal:  J Nucl Med       Date:  1987-10       Impact factor: 10.057

5.  Inverse relationship between cardiac accumulation of meta-[131I]iodobenzylguanidine (I-131 MIBG) and circulating catecholamines in suspected pheochromocytoma.

Authors:  M Nakajo; B Shapiro; J Glowniak; J C Sisson; W H Beierwaltes
Journal:  J Nucl Med       Date:  1983-12       Impact factor: 10.057

6.  Iodine-131 metaiodobenzylguanidine intra- and extravesicular accumulation in the rat heart.

Authors:  M Nakajo; K Shimabukuro; H Yoshimura; R Yonekura; Y Nakabeppu; P Tanoue; S Shinohara
Journal:  J Nucl Med       Date:  1986-01       Impact factor: 10.057

7.  Rapid clearance of iodine-131 MIBG from the heart and liver of patients with adrenergic dysfunction and pheochromocytoma.

Authors:  M Nakajo; K Shimabukuro; N Miyaji; J Shimada; K Shirono; H Sakata; H Yoshimura; R Yonekura; S Shinohara
Journal:  J Nucl Med       Date:  1985-04       Impact factor: 10.057

8.  Effect of alpha-adrenoceptor antagonists (phentolamine, nicergoline and prazosin) on reperfusion arrhythmias and noradrenaline release in perfused rat heart.

Authors:  J Bralet; J Didier; D Moreau; L H Opie; L Rochette
Journal:  Br J Pharmacol       Date:  1985-01       Impact factor: 8.739

9.  Effect of labetalol on the accumulation and release of noradrenaline in rat ventricle.

Authors:  S A Doggrell; D M Paton
Journal:  Eur J Pharmacol       Date:  1978-10-01       Impact factor: 4.432

10.  Comparison of the sodium dependency of uptake of meta-lodobenzylguanidine and norepinephrine into cultured bovine adrenomedullary cells.

Authors:  S Jaques; M C Tobes; J C Sisson; J A Baker; D M Wieland
Journal:  Mol Pharmacol       Date:  1984-11       Impact factor: 4.436
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  10 in total

Review 1.  MIBG imaging.

Authors:  Amar D Patel; Ami E Iskandrian
Journal:  J Nucl Cardiol       Date:  2002 Jan-Feb       Impact factor: 5.952

2.  Effects of therapy with amiodarone on clinical, functional, and cardiac sympathetic innervation in patients with idiopathic dilated cardiomyopathy.

Authors:  Albert Flotats; Ignasi Carrió
Journal:  J Nucl Cardiol       Date:  2004 Mar-Apr       Impact factor: 5.952

Review 3.  Cardiac neurotransmission SPECT imaging.

Authors:  Albert Flotats; Ignasi Carrió
Journal:  J Nucl Cardiol       Date:  2004 Sep-Oct       Impact factor: 5.952

4.  Interaction of metaiodobenzylguanidine with cardioactive drugs: an in vitro study.

Authors:  F Huguet; D Fagret; M Caillet; A Piriou; J C Besnard; D Guilloteau
Journal:  Eur J Nucl Med       Date:  1996-05

5.  Role of cardiac nuclear imaging in the management of critically ill patients.

Authors:  Alia Fattah
Journal:  Eur J Nucl Med Mol Imaging       Date:  2008-09       Impact factor: 9.236

Review 6.  Impact of medications on mIBG uptake, with specific attention to the heart: Comprehensive review of the literature.

Authors:  Arnold F Jacobson; Mark I Travin
Journal:  J Nucl Cardiol       Date:  2015-05-15       Impact factor: 5.952

Review 7.  Radioiodinated metaiodobenzylguanidine: a review of its biodistribution and pharmacokinetics, drug interactions, cytotoxicity and dosimetry.

Authors:  A R Wafelman; C A Hoefnagel; R A Maes; J H Beijnen
Journal:  Eur J Nucl Med       Date:  1994-06

Review 8.  Iodine 123-labeled metaiodobenzylguanidine imaging in heart disease.

Authors:  P Merlet; H Valette; J L Dubois-Randé; K Mardon; F Pouillart; M L Bourachot; A Castaigne; A Syrota
Journal:  J Nucl Cardiol       Date:  1994 Mar-Apr       Impact factor: 5.952

9.  Myocardial iodine-labeled metaiodobenzylguanidine 123 uptake relates to age.

Authors:  M Estorch; I Carrió; L Berná; J López-Pousa; G Torres
Journal:  J Nucl Cardiol       Date:  1995 Mar-Apr       Impact factor: 5.952

10.  Noradrenaline depletion in patients with coronary artery disease before and after percutaneous transluminal coronary angioplasty with iodine-123 metaiodobenzylguanidine and single-photon emission tomography.

Authors:  C Guertner; H Klepzig; F D Maul; A Hartmann; S Lelbach; A Hellmann; G Hoer
Journal:  Eur J Nucl Med       Date:  1993-09
  10 in total

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