Literature DB >> 9420702

Iodine 123-labeled metaiodobenzylguanidine imaging in heart disease.

P Merlet1, H Valette, J L Dubois-Randé, K Mardon, F Pouillart, M L Bourachot, A Castaigne, A Syrota.   

Abstract

Scintigraphic images of myocardial iodine 123-labeled metaiodobenzylguanidine (MIBG) reflect the relative distribution of adrenergic neurodensity and function in the myocardium. In patients with hypertrophic cardiomyopathy or after infarction, MIBG uptake in hypertrophied myocardium and the infarct-related myocardium was found to be decreased in comparison to blood flow distribution, delineated with thallium 201. Most intriguingly, semiquantitative measurements in patients with congestive heart failure demonstrated reduced myocardial MIBG uptake. This reduction correlated directly with indexes of left ventricular function. Decreases in neuronal density, dysfunction of adrenergic neurons, or chronically elevated circulating norepinephrine levels may account for this diminished myocardial uptake, which, as demonstrated in a pilot study of 90 patients with congestive heart failure, was found to be of predictive value for survival.

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Year:  1994        PMID： 9420702     DOI： 10.1007/bf02940073

Source DB:  PubMed          Journal:  J Nucl Cardiol        ISSN： 1071-3581            Impact factor:   5.952


  41 in total

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Journal:  N Engl J Med       Date:  1987-03-26       Impact factor: 91.245

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Journal:  J Nucl Med       Date:  1981-01       Impact factor: 10.057

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Journal:  Mol Pharmacol       Date:  1984-11       Impact factor: 4.436

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Journal:  Am J Cardiol       Date:  1991-02-01       Impact factor: 2.778
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  5 in total

1.  The MIBG tarot: is it possible to predict the efficacy of beta-blockers in congestive heart failure?

Authors:  R R Baliga; J Narula; G W Dec
Journal:  J Nucl Cardiol       Date:  2001 Jan-Feb       Impact factor: 5.952

2.  Will innervation imaging predict ventricular arrhythmias in ischaemic cardiomyopathy?

Authors:  Maureen M Henneman; Frank M Bengel; Jeroen J Bax
Journal:  Eur J Nucl Med Mol Imaging       Date:  2006-08       Impact factor: 9.236

3.  Influence of the polyol pathway on norepinephrine transporter reduction in diabetic cardiac sympathetic nerves: implications for heterogeneous accumulation of MIBG.

Authors:  Yasushi Kiyono; Satomi Kajiyama; Hiromi Fujiwara; Naoki Kanegawa; Hideo Saji
Journal:  Eur J Nucl Med Mol Imaging       Date:  2004-11-26       Impact factor: 9.236

4.  Influence of the polyol pathway on norepinephrine transporter reduction in diabetic cardiac sympathetic nerves: implications for heterogeneous accumulation of MIBG.

Authors:  Yasushi Kiyono; Satomi Kajiyama; Hiromi Fujiwara; Naoki Kanegawa; Hideo Saji
Journal:  Eur J Nucl Med Mol Imaging       Date:  2005-08       Impact factor: 9.236

5.  Cardiac autonomic nervous system in heart failure: imaging technique and clinical implications.

Authors:  Mark J Boogers; Caroline E Veltman; Jeroen J Bax
Journal:  Curr Cardiol Rev       Date:  2011-02
  5 in total

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