Marc Dirix1, Tine van Becelaere1, Lizanne Berkenbosch1, Robertine van Baren2, Rene M Wijnen3, Marc H Wijnen4, David C van der Zee5, Hugo A Heij6, Joep P M Derikx1, L W Ernest van Heurn7. 1. Department of Pediatric Surgery, Maastricht University Medical Centre, The Netherlands. 2. Department of Pediatric Surgery, University Medical Centre Groningen, The Netherlands. 3. Department of Pediatric Surgery, Erasmus Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands. 4. Department of Pediatric Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands. 5. Department of Pediatric Surgery, Wilhelmina Children's Hospital, University Medical Centre, Utrecht, The Netherlands. 6. Pediatric Surgical Centre of Amsterdam (Emma Children's Hospital AMC/VU University Medical Centre), The Netherlands. 7. Department of Pediatric Surgery, Maastricht University Medical Centre, The Netherlands. Electronic address: e.van.heurn@mumc.nl.
Abstract
BACKGROUND/ PURPOSE: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. METHODS: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. RESULTS: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p=0.017) CONCLUSIONS: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small.
BACKGROUND/ PURPOSE: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. METHODS: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. RESULTS: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p=0.017) CONCLUSIONS: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small.
Authors: Marijke E B Kremer; Joep P M Derikx; Leontien C M Kremer; Robertine van Baren; Hugo A Heij; Marc H W A Wijnen; René M H Wijnen; David C van der Zee; L W Ernest van Heurn Journal: Pediatr Surg Int Date: 2015-12-14 Impact factor: 1.827
Authors: Marijke E B Kremer; Margot M Koeneman; Joep P M Derikx; Audrey Coumans; Robertine van Baren; Hugo A Heij; Marc H W A Wijnen; René M H Wijnen; David C van der Zee; Ernest L W van Heurn Journal: BMC Pregnancy Childbirth Date: 2014-12-12 Impact factor: 3.007