Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Overcoming transport barriers for interstitial-, lymphatic-, and lymph node-targeted drug delivery.

Literature DB >> 25745594

Overcoming transport barriers for interstitial-, lymphatic-, and lymph node-targeted drug delivery.

Abstract

Despite drug formulation improving circulation times and targeting, efficacy is stymied by inadequate penetration into and retention within target tissues. This review highlights the barriers restricting delivery to the connective tissue interstitium, lymphatics, and lymph nodes as well as advances in engineering drug carriers to overcome these delivery challenges. Three-dimensional tissue physiology is discussed in the context of providing material design principles for delivery to these tissues; in particular the influence of interstitial and lymphatic flows as well as differential permeabilities of the blood and lymphatic capillaries. Key examples of materials with different characteristics developed to overcome these transport barriers are discussed as well as potential areas for further development.

Entities: Chemical Disease Gene Species

Keywords: drug delivery; interstitium; lymph node; lymphatics

Year: 2015 PMID： 25745594 PMCID： PMC4345645 DOI： 10.1016/j.coche.2014.11.003

Source DB: PubMed Journal: Curr Opin Chem Eng ISSN： 2211-3398 Impact factor: 5.163

63 in total

1. Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors.

Authors: Robert B Campbell; Dai Fukumura; Edward B Brown; Laureen M Mazzola; Yotaro Izumi; Rakesh K Jain; Vladimir P Torchilin; Lance L Munn
Journal: Cancer Res Date: 2002-12-01 Impact factor: 12.701

2. Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors.

Authors: George Alexandrakis; Edward B Brown; Ricky T Tong; Trevor D McKee; Robert B Campbell; Yves Boucher; Rakesh K Jain
Journal: Nat Med Date: 2004-01-11 Impact factor: 53.440

Review 3. Dendritic-cell trafficking to lymph nodes through lymphatic vessels.

Authors: Gwendalyn J Randolph; Veronique Angeli; Melody A Swartz
Journal: Nat Rev Immunol Date: 2005-08 Impact factor: 53.106

4. Shape effects of filaments versus spherical particles in flow and drug delivery.

Authors: Yan Geng; Paul Dalhaimer; Shenshen Cai; Richard Tsai; Manorama Tewari; Tamara Minko; Dennis E Discher
Journal: Nat Nanotechnol Date: 2007-03-25 Impact factor: 39.213

5. Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose.

Authors: Alexandre de Titta; Marie Ballester; Ziad Julier; Chiara Nembrini; Laura Jeanbart; André J van der Vlies; Melody A Swartz; Jeffrey A Hubbell
Journal: Proc Natl Acad Sci U S A Date: 2013-11-18 Impact factor: 11.205

6. Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions.

Authors: Triantafyllos Stylianopoulos; Ming-Zher Poh; Numpon Insin; Moungi G Bawendi; Dai Fukumura; Lance L Munn; Rakesh K Jain
Journal: Biophys J Date: 2010-09-08 Impact factor: 4.033

Review 7. Interstitial-lymphatic mechanisms in the control of extracellular fluid volume.

Authors: K Aukland; R K Reed
Journal: Physiol Rev Date: 1993-01 Impact factor: 37.312

Review 8. PEG hydrogels for the controlled release of biomolecules in regenerative medicine.

Authors: Chien-Chi Lin; Kristi S Anseth
Journal: Pharm Res Date: 2008-12-18 Impact factor: 4.200

9. Size effect of amphiphilic poly(γ-glutamic acid) nanoparticles on cellular uptake and maturation of dendritic cells in vivo.

Authors: Fumiaki Shima; Tomofumi Uto; Takami Akagi; Masanori Baba; Mitsuru Akashi
Journal: Acta Biomater Date: 2013-06-14 Impact factor: 8.947

10. Hyaluronidase enhances the activity of adriamycin in breast cancer models in vitro and in vivo.

Authors: K Beckenlehner; S Bannke; T Spruss; G Bernhardt; H Schönenberg; W Schiess
Journal: J Cancer Res Clin Oncol Date: 1992 Impact factor: 4.553

34 in total

1. Melanoma growth effects on molecular clearance from tumors and biodistribution into systemic tissues versus draining lymph nodes.

Authors: Nathan Andrew Rohner; Susan Napier Thomas
Journal: J Control Release Date: 2015-12-23 Impact factor: 9.776

2. S-Nitrosated Polypropylene Sulfide Nanoparticles for Thiol-Dependent Transnitrosation and Toxicity Against Adult Female Filarial Worms.

Authors: Alex Schudel; Timothy Kassis; J Brandon Dixon; Susan N Thomas
Journal: Adv Healthc Mater Date: 2015-05-04 Impact factor: 9.933

3. Flexible Macromolecule versus Rigid Particle Retention in the Injected Skin and Accumulation in Draining Lymph Nodes Are Differentially Influenced by Hydrodynamic Size.

Authors: Nathan Andrew Rohner; Susan Napier Thomas
Journal: ACS Biomater Sci Eng Date: 2016-11-18

4. Lymph node biophysical remodeling is associated with melanoma lymphatic drainage.

Authors: Nathan Andrew Rohner; Jacob McClain; Sara Lydia Tuell; Alex Warner; Blair Smith; Youngho Yun; Abhinav Mohan; Manuela Sushnitha; Susan Napier Thomas
Journal: FASEB J Date: 2015-07-15 Impact factor: 5.191

Review 5. Surface engineering for lymphocyte programming.

Authors: Elana Ben-Akiva; Randall A Meyer; David R Wilson; Jordan J Green
Journal: Adv Drug Deliv Rev Date: 2017-05-10 Impact factor: 15.470

Review 6. Implications of Lymphatic Transport to Lymph Nodes in Immunity and Immunotherapy.

Authors: Susan N Thomas; Nathan A Rohner; Erin E Edwards
Journal: Annu Rev Biomed Eng Date: 2016-02-24 Impact factor: 9.590

Review 7. Engineering immunity: Modulating dendritic cell subsets and lymph node response to direct immune-polarization and vaccine efficacy.

Authors: Jardin Leleux; Alexandra Atalis; Krishnendu Roy
Journal: J Control Release Date: 2015-10-20 Impact factor: 9.776