Arno Kerling1, Uwe Tegtbur1, Elke Gützlaff1, Momme Kück1, Luise Borchert2, Zeynep Ates2, Anne von Bohlen2, Helge Frieling2, Katja Hüper3, Dagmar Hartung3, Ulrich Schweiger4, Kai G Kahl5. 1. Institute of Sports Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. 2. Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. 3. Institute for Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. 4. Department of Psychiatry and Psychotherapy, University of Lübeck, Ratzeburger Allee 160, Lübeck, Germany. 5. Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. Electronic address: kahl.kai@mh-hannover.de.
Abstract
OBJECTIVE:Major depressive disorder (MDD) is associated with decreased physical activity and increased rates of the metabolic syndrome (MetS), a risk factor for the development of type 2 diabetes and cardiovascular disorders. Exercise training has been shown to improve cardiorespiratory fitness and metabolic syndrome factors. Therefore, our study aimed at examining whether patients receiving anexercise program as an adjunct to inpatient treatment will benefit in terms of physiological and psychological factors. METHOD: Fourty-two inpatients with moderate to severe depression were included. Twenty-two patients were randomized to additional 3x weekly exercise training (EXERCISE) and compared to treatment as usual (TAU). Exercise capacity was assessed as peak oxygen uptake (VO2peak), ventilatory anaerobic threshold (VAT) and workload expressed as Watts (W). Metabolic syndrome was defined according to NCEP ATPIII panel criteria. RESULTS: After 6 weeks of treatment, cardiorespiratory fitness (VO2peak, VAT, Watt), waist circumference and HDL cholesterol were significantly improved in EXERCISE participants. Treatment response expressed as ≥50% MADRS reduction was more frequent in the EXERCISE group. CONCLUSIONS:Adjunctive exercise training in depressed inpatients improves physical fitness, MetS factors, and psychological outcome. Given the association of depression with cardiometablic disorders, exercise training is recommended as an adjunct to standard antidepressant treatment.
RCT Entities:
OBJECTIVE: Major depressive disorder (MDD) is associated with decreased physical activity and increased rates of the metabolic syndrome (MetS), a risk factor for the development of type 2 diabetes and cardiovascular disorders. Exercise training has been shown to improve cardiorespiratory fitness and metabolic syndrome factors. Therefore, our study aimed at examining whether patients receiving an exercise program as an adjunct to inpatient treatment will benefit in terms of physiological and psychological factors. METHOD: Fourty-two inpatients with moderate to severe depression were included. Twenty-two patients were randomized to additional 3x weekly exercise training (EXERCISE) and compared to treatment as usual (TAU). Exercise capacity was assessed as peak oxygen uptake (VO2peak), ventilatory anaerobic threshold (VAT) and workload expressed as Watts (W). Metabolic syndrome was defined according to NCEP ATPIII panel criteria. RESULTS: After 6 weeks of treatment, cardiorespiratory fitness (VO2peak, VAT, Watt), waist circumference and HDL cholesterol were significantly improved in EXERCISE participants. Treatment response expressed as ≥50% MADRS reduction was more frequent in the EXERCISE group. CONCLUSIONS: Adjunctive exercise training in depressed inpatients improves physical fitness, MetS factors, and psychological outcome. Given the association of depression with cardiometablic disorders, exercise training is recommended as an adjunct to standard antidepressant treatment.
Authors: Amjad M Ahmed; Waqas T Qureshi; Sherif Sakr; Michael J Blaha; Clinton A Brawner; Jonathan K Ehrman; Steven J Keteyian; Mouaz H Al-Mallah Journal: Clin Cardiol Date: 2018-04-17 Impact factor: 2.882
Authors: Lisa A Uebelacker; Marie A Sillice; Gary Epstein-Lubow; Cynthia L Battle; Bradley Anderson; Celeste Caviness; Ivan W Miller; Ana M Abrantes Journal: Contemp Clin Trials Date: 2020-03-07 Impact factor: 2.226
Authors: Davy Vancampfort; Simon Rosenbaum; Felipe Schuch; Philip B Ward; Justin Richards; James Mugisha; Michel Probst; Brendon Stubbs Journal: Sports Med Date: 2017-02 Impact factor: 11.136
Authors: Brendon Stubbs; Davy Vancampfort; Simon Rosenbaum; Philip B Ward; Justin Richards; Michael Ussher; Felipe B Schuch Journal: Sports Med Date: 2016-05 Impact factor: 11.136