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Literature DB >> 2574306

Prenatal sex determination by DNA amplification from maternal peripheral blood.

Y M Lo¹, P Patel, J S Wainscoat, M Sampietro, M D Gillmer, K A Fleming.

Abstract

The polymerase chain reaction was used to amplify a Y-specific repeat sequence in peripheral blood DNA samples from 19 pregnant women who had a gestational age of 9 to 41 weeks. Y-specific sequences were amplified from all 12 women who bore a male fetus but in none of 7 women who bore a female fetus. With stringent precautions against contamination, this technique may assist prenatal diagnosis of sex-linked genetic disorders.

Entities: Disease Species

Mesh：

Substances：
Genetic Markers

Year: 1989 PMID： 2574306 DOI： 10.1016/s0140-6736(89)91969-7

Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321

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Cited

39 in total

1. Gene analysis of free fetal DNA in maternal plasma.

Authors: H Chen; T Wang; G He; L Zhu; T Ma
Journal: J Tongji Med Univ Date: 2001

2. MS analysis of single-nucleotide differences in circulating nucleic acids: Application to noninvasive prenatal diagnosis.

Authors: Chunming Ding; Rossa W K Chiu; Tze K Lau; Tse N Leung; Li C Chan; Amy Y Y Chan; Pimlak Charoenkwan; Ivy S L Ng; Hai-Yang Law; Edmond S K Ma; Xiangmin Xu; Chanane Wanapirak; Torpong Sanguansermsri; Can Liao; Mary Anne Tan Jin Ai; David H K Chui; Charles R Cantor; Y M Dennis Lo
Journal: Proc Natl Acad Sci U S A Date: 2004-07-09 Impact factor: 11.205

Review 3. Prenatal diagnosis of enzyme defects--an update.

Authors: B Winchester; E Young
Journal: Arch Dis Child Date: 1991-04 Impact factor: 3.791

Review 4. Medical genetics.

Authors: M Super
Journal: Postgrad Med J Date: 1991-07 Impact factor: 2.401

Prenatal sex determination by DNA amplification from maternal peripheral blood.

1. Gene analysis of free fetal DNA in maternal plasma.

2. MS analysis of single-nucleotide differences in circulating nucleic acids: Application to noninvasive prenatal diagnosis.

Review 3. Prenatal diagnosis of enzyme defects--an update.

Review 4. Medical genetics.

5. Sexing of forensic samples using PCR.

6. The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells.

7. Optimal polymerase chain reaction amplification for preimplantation diagnosis in cystic fibrosis (delta F508)

Review 8. The polymerase chain reaction in pathology.

Review 9. Fetal cells in maternal circulation: progress in analysis of a rare event.

10. Fetal cells in the maternal circulation during first trimester in pregnancies.