Literature DB >> 25740993

BH3 Profiling Reveals Selectivity by Herpesviruses for Specific Bcl-2 Proteins To Mediate Survival of Latently Infected Cells.

Olesea Cojohari1, Christine M Burrer1, Megan A Peppenelli1, Fardokht A Abulwerdi2, Zaneta Nikolovska-Coleska2, Gary C Chan3.   

Abstract

Herpesviruses, including human cytomegalovirus (HCMV), Epstein-Barr virus (EBV), and Kaposi's sarcoma-associated herpesvirus, establish latency by modulating or mimicking antiapoptotic Bcl-2 proteins to promote survival of carrier cells. BH3 profiling, which assesses the contribution of Bcl-2 proteins towards cellular survival, was able to globally determine the level of dependence on individual cellular and viral Bcl-2 proteins within latently infected cells. Moreover, BH3 profiling predicted the sensitivity of infected cells to small-molecule inhibitors of Bcl-2 proteins.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25740993      PMCID： PMC4442507          DOI： 10.1128/JVI.00236-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  63 in total

1.  Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arrays.

Authors:  R G Jenner; M M Albà; C Boshoff; P Kellam
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

2.  A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2.

Authors:  V S Goldmacher; L M Bartle; A Skaletskaya; C A Dionne; N L Kedersha; C A Vater; J W Han; R J Lutz; S Watanabe; E D Cahir McFarland; E D Kieff; E S Mocarski; T Chittenden
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-26       Impact factor: 11.205

3.  Role of the laboratory in diagnosis and management of cytomegalovirus infection in hematopoietic stem cell and solid-organ transplant recipients.

Authors:  Raymund R Razonable; Carlos V Paya; Thomas F Smith
Journal:  J Clin Microbiol       Date:  2002-03       Impact factor: 5.948

4.  A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation.

Authors:  A Skaletskaya; L M Bartle; T Chittenden; A L McCormick; E S Mocarski; V S Goldmacher
Journal:  Proc Natl Acad Sci U S A       Date:  2001-06-26       Impact factor: 11.205

5.  Kaposi's sarcoma-associated herpesvirus encodes a functional bcl-2 homologue.

Authors:  R Sarid; T Sato; R A Bohenzky; J J Russo; Y Chang
Journal:  Nat Med       Date:  1997-03       Impact factor: 53.440

6.  Kaposi sarcoma-associated herpesvirus infects monotypic (IgM lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders.

Authors:  M Q Du; H Liu; T C Diss; H Ye; R A Hamoudi; N Dupin; V Meignin; E Oksenhendler; C Boshoff; P G Isaacson
Journal:  Blood       Date:  2001-04-01       Impact factor: 22.113

Review 7.  Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8): epidemiology and pathogenesis.

Authors:  T F Schulz
Journal:  J Antimicrob Chemother       Date:  2000-04       Impact factor: 5.790

8.  A prospective study of the natural course of cytomegalovirus infection and disease in renal allograft recipients.

Authors:  S Sagedal; K P Nordal; A Hartmann; M Degré; E Holter; A Foss; K Osnes; T Leivestad; P Fauchald; H Rollag
Journal:  Transplantation       Date:  2000-10-27       Impact factor: 4.939

Review 9.  Management of cytomegalovirus infection and disease after solid-organ transplantation.

Authors:  W van der Bij; R Speich
Journal:  Clin Infect Dis       Date:  2001-07-01       Impact factor: 9.079

10.  Epstein-Barr virus BALF1 is a BCL-2-like antagonist of the herpesvirus antiapoptotic BCL-2 proteins.

Authors:  David S Bellows; Melanie Howell; Colin Pearson; Sheila A Hazlewood; J Marie Hardwick
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103
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  10 in total

1.  Locating Herpesvirus Bcl-2 Homologs in the Specificity Landscape of Anti-Apoptotic Bcl-2 Proteins.

Authors:  Glenna Wink Foight; Amy E Keating
Journal:  J Mol Biol       Date:  2015-05-23       Impact factor: 5.469

2.  Mcl-1 small-molecule inhibitors encapsulated into nanoparticles exhibit increased killing efficacy towards HCMV-infected monocytes.

Authors:  Christine M Burrer; Helen Auburn; Xu Wang; Juntao Luo; Fardokht A Abulwerdi; Zaneta Nikolovska-Coleska; Gary C Chan
Journal:  Antiviral Res       Date:  2016-11-30       Impact factor: 5.970

3.  Human Cytomegalovirus Stimulates the Synthesis of Select Akt-Dependent Antiapoptotic Proteins during Viral Entry To Promote Survival of Infected Monocytes.

Authors:  Megan A Peppenelli; Kyle C Arend; Olesea Cojohari; Nathaniel J Moorman; Gary C Chan
Journal:  J Virol       Date:  2016-01-06       Impact factor: 5.103

4.  Human Cytomegalovirus-Induced Autophagy Prevents Necroptosis of Infected Monocytes.

Authors:  Aaron M Altman; Michael J Miller; Jamil Mahmud; Nicholas A Smith; Gary C Chan
Journal:  J Virol       Date:  2020-10-27       Impact factor: 5.103

5.  Human Cytomegalovirus Induces an Atypical Activation of Akt To Stimulate the Survival of Short-Lived Monocytes.

Authors:  Olesea Cojohari; Megan A Peppenelli; Gary C Chan
Journal:  J Virol       Date:  2016-06-24       Impact factor: 5.103

6.  Selective peptide inhibitors of antiapoptotic cellular and viral Bcl-2 proteins lead to cytochrome c release during latent Kaposi's sarcoma-associated herpesvirus infection.

Authors:  Christine M Burrer; Glenna W Foight; Amy E Keating; Gary C Chan
Journal:  Virus Res       Date:  2015-10-09       Impact factor: 3.303

7.  Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection.

Authors:  Alexander M Price; Joanne Dai; Quentin Bazot; Luv Patel; Pavel A Nikitin; Reza Djavadian; Peter S Winter; Cristina A Salinas; Ashley Perkins Barry; Kris C Wood; Eric C Johannsen; Anthony Letai; Martin J Allday; Micah A Luftig
Journal:  Elife       Date:  2017-04-20       Impact factor: 8.140

8.  Human Cytomegalovirus Mediates Unique Monocyte-to-Macrophage Differentiation through the PI3K/SHIP1/Akt Signaling Network.

Authors:  Olesea Cojohari; Jamil Mahmud; Aaron M Altman; Megan A Peppenelli; Michael J Miller; Gary C Chan
Journal:  Viruses       Date:  2020-06-17       Impact factor: 5.048

9.  Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma.

Authors:  Mark Manzano; Ajinkya Patil; Alexander Waldrop; Sandeep S Dave; Amir Behdad; Eva Gottwein
Journal:  Nat Commun       Date:  2018-08-15       Impact factor: 14.919

10.  Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques.

Authors:  Benjamin J Burwitz; Daniel Malouli; Benjamin N Bimber; Jason S Reed; Abigail B Ventura; Meaghan H Hancock; Luke S Uebelhoer; Amruta Bhusari; Katherine B Hammond; Renee G Espinosa Trethewy; Alex Klug; Alfred W Legasse; Michael K Axthelm; Jay A Nelson; Byung S Park; Daniel N Streblow; Scott G Hansen; Louis J Picker; Klaus Früh; Jonah B Sacha
Journal:  PLoS Pathog       Date:  2016-11-09       Impact factor: 6.823
  10 in total

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