BACKGROUND: Impaired glucose metabolism plays an important role in patients with acute myocardial infarction, but the clinical significance of glycemic variability (GV) early after the onset of ST-segment elevation myocardial infarction (STEMI) remains to be fully elucidated. METHODS AND RESULTS: We prospectively investigated the clinical impact of GV, as determined by a continuous glucose monitoring system (CGMS), on left ventricular remodeling (LVR) assessed by cardiac magnetic resonance imaging (CMR) in 69 patients (63±13 years, 59 men) with a first reperfused STEMI within 12 h of onset. All patients were equipped with a CGMS when in a stable phase after admission and underwent repeat CMR at baseline and 7 months follow-up. Patients were divided into 2 groups according to the mean amplitude of glycemic excursions (MAGE). Patients in the upper tertile of MAGE were categorized as group High (H) and the other two-thirds as group Low (L). LVR was defined as an absolute increase in left ventricular end-diastolic volume index of ≥20%. LVR more frequently occurred in group H than in group L (56% vs. 11%, P<0.001). Multivariate analysis showed the higher MAGE group was an independent predictor of LVR in the chronic phase (odds ratio, 13.999; 95% confidence interval, 3.059 to 64.056; P=0.001). CONCLUSIONS: MAGE early after the onset of STEMI identified patients with LVR in the chronic phase.
BACKGROUND: Impaired glucose metabolism plays an important role in patients with acute myocardial infarction, but the clinical significance of glycemic variability (GV) early after the onset of ST-segment elevation myocardial infarction (STEMI) remains to be fully elucidated. METHODS AND RESULTS: We prospectively investigated the clinical impact of GV, as determined by a continuous glucose monitoring system (CGMS), on left ventricular remodeling (LVR) assessed by cardiac magnetic resonance imaging (CMR) in 69 patients (63±13 years, 59 men) with a first reperfused STEMI within 12 h of onset. All patients were equipped with a CGMS when in a stable phase after admission and underwent repeat CMR at baseline and 7 months follow-up. Patients were divided into 2 groups according to the mean amplitude of glycemic excursions (MAGE). Patients in the upper tertile of MAGE were categorized as group High (H) and the other two-thirds as group Low (L). LVR was defined as an absolute increase in left ventricular end-diastolic volume index of ≥20%. LVR more frequently occurred in group H than in group L (56% vs. 11%, P<0.001). Multivariate analysis showed the higher MAGE group was an independent predictor of LVR in the chronic phase (odds ratio, 13.999; 95% confidence interval, 3.059 to 64.056; P=0.001). CONCLUSIONS: MAGE early after the onset of STEMI identified patients with LVR in the chronic phase.
Authors: Damien Legallois; Amir Hodzic; Joachim Alexandre; Charles Dolladille; Eric Saloux; Alain Manrique; Vincent Roule; Fabien Labombarda; Paul Milliez; Farzin Beygui Journal: Heart Fail Rev Date: 2022-01 Impact factor: 4.214
Authors: Maria Isabel Del Olmo-García; David Hervás Marín; Jana Caudet Esteban; Antonio Ballesteros Martin-Portugués; Alba Cerveró Rubio; Miguel Angel Arnau Vives; Ana Catalá Gregori; Maite Penalba Martínez; Juan Francisco Merino-Torres Journal: J Int Med Res Date: 2020-06 Impact factor: 1.671
Authors: Edouard Gerbaud; Ambroise Bouchard de La Poterie; Thomas Baudinet; Michel Montaudon; Marie-Christine Beauvieux; Anne-Iris Lemaître; Laura Cetran; Benjamin Seguy; François Picard; Fritz-Line Vélayoudom; Alexandre Ouattara; Rémi Kabore; Pierre Coste; Pierre Domingues-Dos-Santos; Bogdan Catargi Journal: J Clin Med Date: 2022-03-11 Impact factor: 4.241