Literature DB >> 2573834

Identification of a germ line transcript from the unrearranged kappa gene in human B cells.

D J Martin1, B G Van Ness.   

Abstract

A novel kappa immunoglobulin-hybridizing mRNA in cell lines derived from human B cells arrested at several stages of development has been identified. Hybridization studies demonstrate that this 1.5-kilobase mRNA species is the spliced product of a precursor germ line transcript initiating upstream of the unrearranged JKappa locus.

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Year:  1989        PMID： 2573834      PMCID： PMC362544          DOI： 10.1128/mcb.9.10.4560-4562.1989

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  29 in total

1.  Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

Authors:  E E Max; J G Seidman; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

2.  Characterization of a unique cell line (LAZ 221) from human acute lymphocytic ("null" cell) leukemia.

Authors:  H Lazarus; E F Barell; A Krishan; D M Livingston; K Harris; S F Schlossman; L Chess
Journal:  Cancer Res       Date:  1978-05       Impact factor: 12.701

3.  Detection of specific RNAs or specific fragments of DNA by fractionation in gels and transfer to diazobenzyloxymethyl paper.

Authors:  J C Alwine; D J Kemp; B A Parker; J Reiser; J Renart; G R Stark; G M Wahl
Journal:  Methods Enzymol       Date:  1979       Impact factor: 1.600

4.  Transcription of the unrearranged mouse C kappa locus: sequence of the initiation region and comparison of activity with a rearranged V kappa-C kappa gene.

Authors:  B G Van Ness; M Weigert; C Coleclough; E L Mather; D E Kelley; R P Perry
Journal:  Cell       Date:  1981-12       Impact factor: 41.582

Review 5.  Somatic generation of antibody diversity.

Authors:  S Tonegawa
Journal:  Nature       Date:  1983-04-14       Impact factor: 49.962

6.  Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments.

Authors:  P A Hieter; E E Max; J G Seidman; J V Maizel; P Leder
Journal:  Cell       Date:  1980-11       Impact factor: 41.582

7.  DNA between variable and joining gene segments of immunoglobulin kappa light chain is frequently retained in cells that rearrange the kappa locus.

Authors:  B G Van Ness; C Coleclough; R P Perry; M Weigert
Journal:  Proc Natl Acad Sci U S A       Date:  1982-01       Impact factor: 11.205

8.  Transcription of mouse kappa chain genes: implications for allelic exclusion.

Authors:  R P Perry; D E Kelley; C Coleclough; J G Seidman; P Leder; S Tonegawa; G Matthyssens; M Weigert
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

9.  Evolution of human immunoglobulin kappa J region genes.

Authors:  P A Hieter; J V Maizel; P Leder
Journal:  J Biol Chem       Date:  1982-02-10       Impact factor: 5.157

10.  Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins.

Authors:  S J Korsmeyer; A Arnold; A Bakhshi; J V Ravetch; U Siebenlist; P A Hieter; S O Sharrow; T W LeBien; J H Kersey; D G Poplack; P Leder; T A Waldmann
Journal:  J Clin Invest       Date:  1983-02       Impact factor: 14.808
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  6 in total

1.  Initiation and processing of two kappa immunoglobulin germ line transcripts in mouse B cells.

Authors:  D J Martin; B G van Ness
Journal:  Mol Cell Biol       Date:  1990-05       Impact factor: 4.272

2.  Re-organization of the immunoglobulin kappa gene on both alleles is not an obligatory prerequisite for Ig lambda gene expression in human cells.

Authors:  H Abken; C Bützler
Journal:  Immunology       Date:  1991-12       Impact factor: 7.397

3.  mRNA transcripts initiating within the human immunoglobulin mu heavy chain enhancer region contain a non-translatable exon and are extremely heterogeneous at the 5' end.

Authors:  G A Neale; G R Kitchingman
Journal:  Nucleic Acids Res       Date:  1991-05-11       Impact factor: 16.971

4.  Octamer independent activation of transcription from the kappa immunoglobulin germline promoter.

Authors:  A Prabhu; D P O'Brien; G L Weisner; R Fulton; B Van Ness
Journal:  Nucleic Acids Res       Date:  1996-12-01       Impact factor: 16.971

5.  The proximal J kappa germline-transcript promoter facilitates receptor editing through control of ordered recombination.

Authors:  Christian Vettermann; Greg A Timblin; Vivian Lim; Ernest C Lai; Mark S Schlissel
Journal:  PLoS One       Date:  2015-01-05       Impact factor: 3.240

6.  Induced rearrangement of kappa genes in the BLIN-1 human pre-B cell line correlates with germline J-C kappa and V kappa transcription.

Authors:  D Martin; R Q Huang; T LeBien; B Van Ness
Journal:  J Exp Med       Date:  1991-03-01       Impact factor: 14.307
  6 in total

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