Literature DB >> 2573813

Feeding pure docosahexaenoate or arachidonate decreases plasma triacylglycerol secretion in rats.

M A Williams1, J Tinoco, Y T Yang, M I Bird, I Hincenbergs.   

Abstract

Essential fatty acid (EFA)-deficient rats were fed highly purified methyl esters of docosahexaenoate (22:6n-3), arachidonate (20:4n-6), alpha-linolenate (18:3n-3) or oleate (18:1n-9) (100 mg/day, tube fed for 3-10 days), and their plasma triacylglycerol (TG) secretion rates were measured. Secretion rates of TG into plasma were reduced by tube-feeding 22:6n-3, 20:4n-6, 18:3n-3, but not 18:1n-9, to EFA-deficient rats. A significant reduction occurred after feeding 22:6n-3 for only three days. Feeding 22:6n-3 or 18:3n-3 to EFA-deficient rats for three days also reduced the activities of liver lipogenic enzymes and sharply increased the proportions of 22:6n-3 and 20:5n-3 in liver phospholipid fractions. Mechanisms by which these EFA may reduce lipogenesis are discussed.

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Year:  1989        PMID： 2573813     DOI： 10.1007/BF02544579

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  50 in total

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Authors:  G R Herzberg
Journal:  Adv Nutr Res       Date:  1983

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Authors:  R R Brenner
Journal:  Mol Cell Biochem       Date:  1974-03-08       Impact factor: 3.396

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Authors:  J O Nossen; A C Rustan; S H Gloppestad; S Målbakken; C A Drevon
Journal:  Biochim Biophys Acta       Date:  1986-10-24

4.  Inhibition of apolipoprotein secretion and phosphatidate phosphohydrolase activity by eicosapentaenoic and docosahexaenoic acids in the perfused rat liver.

Authors:  S H Wong; J B Marsh
Journal:  Metabolism       Date:  1988-12       Impact factor: 8.694

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Authors:  T Fukazawa; O S Privett; Y Takahaski
Journal:  J Lipid Res       Date:  1970-11       Impact factor: 5.922

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Authors:  M Yamamoto; I Yamamoto; Y Tanaka; J A Ontko
Journal:  J Lipid Res       Date:  1987-10       Impact factor: 5.922

7.  A diet rich in (n-3) fatty acids increases peroxisomal beta-oxidation activity and lowers plasma triacylglycerols without inhibiting glutathione-dependent detoxication activities in the rat liver.

Authors:  R K Yamazaki; T Shen; G B Schade
Journal:  Biochim Biophys Acta       Date:  1987-07-13

8.  Hepatic fatty acid synthesis and triglyceride secretion in rats fed fructose- or glucose-based diets containing corn oil, tallow or marine oil.

Authors:  G R Herzberg; M Rogerson
Journal:  J Nutr       Date:  1988-09       Impact factor: 4.798

9.  Increased plasma triglyceride secretion in EFA-deficient rats fed diets with or without saturated fat.

Authors:  M A Williams; J Tinoco; I Hincenbergs; B Thomas
Journal:  Lipids       Date:  1989-05       Impact factor: 1.880

10.  Hydrogenated coconut oil and tissue fatty acids in EFA-depleted and EFA-supplemented rats.

Authors:  M A Williams; K T Tamai; I Hincenbergs; D J McIntosh
Journal:  J Nutr       Date:  1972-07       Impact factor: 4.798
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  5 in total

1.  Eicosapentaenoic acid, but not docosahexaenoic acid, increases mitochondrial fatty acid oxidation and upregulates 2,4-dienoyl-CoA reductase gene expression in rats.

Authors:  N Willumsen; H Vaagenes; O Lie; A C Rustan; R K Berge
Journal:  Lipids       Date:  1996-06       Impact factor: 1.880

2.  Lipid peroxidation and antioxidant status is affected by different vitamin E levels when feeding fish oil.

Authors:  S H Cho; Y S Choi
Journal:  Lipids       Date:  1994-01       Impact factor: 1.880

3.  Evidence that dietary arachidonic acid increases circulating triglycerides.

Authors:  J Whelan; M E Surette; B Li-Stiles; J W Bailey
Journal:  Lipids       Date:  1995-05       Impact factor: 1.880

4.  Effect of 4,7,10,13,16,19-docosahexaenoic acid on triglyceride accumulation and secretion in rat hepatocytes in culture.

Authors:  L J Martin; G B Reaidi; G R Gavino; V C Gavino
Journal:  Lipids       Date:  1991-05       Impact factor: 1.880

5.  Mechanisms of lipid malabsorption in Cystic Fibrosis: the impact of essential fatty acids deficiency.

Authors:  N Peretti; V Marcil; E Drouin; E Levy
Journal:  Nutr Metab (Lond)       Date:  2005-05-03       Impact factor: 4.169
  5 in total

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