Literature DB >> 25736003

Myelodysplastic syndromes, version 2.2015.

Peter L Greenberg1, Richard M Stone1, Rafael Bejar1, John M Bennett1, Clara D Bloomfield1, Uma Borate1, Carlos M De Castro1, H Joachim Deeg1, Amy E DeZern1, Amir T Fathi1, Olga Frankfurt1, Karin Gaensler1, Guillermo Garcia-Manero1, Elizabeth A Griffiths1, David Head1, Virginia Klimek1, Rami Komrokji1, Lisa A Kujawski1, Lori J Maness1, Margaret R O'Donnell1, Daniel A Pollyea1, Bart Scott1, Paul J Shami1, Brady L Stein1, Peter Westervelt1, Benton Wheeler1, Dorothy A Shead1, Courtney Smith1.   

Abstract

The NCCN Guidelines for Myelodysplastic Syndromes (MDS) comprise a heterogeneous group of myeloid disorders with a highly variable disease course that depends largely on risk factors. Risk evaluation is therefore a critical component of decision-making in the treatment of MDS. The development of newer treatments and the refinement of current treatment modalities are designed to improve patient outcomes and reduce side effects. These NCCN Guidelines Insights focus on the recent updates to the guidelines, which include the incorporation of a revised prognostic scoring system, addition of molecular abnormalities associated with MDS, and refinement of treatment options involving a discussion of cost of care.
Copyright © 2015 by the National Comprehensive Cancer Network.

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Year:  2015        PMID: 25736003      PMCID: PMC4696005          DOI: 10.6004/jnccn.2015.0038

Source DB:  PubMed          Journal:  J Natl Compr Canc Netw        ISSN: 1540-1405            Impact factor:   11.908


  50 in total

1.  Chromosomal alterations associated with evolution from myelodysplastic syndrome to acute myeloid leukemia.

Authors:  T de Souza Fernandez; M H Ornellas; L Otero de Carvalho; D Tabak; E Abdelhay
Journal:  Leuk Res       Date:  2000-10       Impact factor: 3.156

2.  The revised IPSS is a powerful tool to evaluate the outcome of MDS patients treated with azacitidine: the GFM experience.

Authors:  Mathilde Lamarque; Sophie Raynaud; Raphael Itzykson; Sylvain Thepot; Bruno Quesnel; Francois Dreyfus; Odile Beyne Rauzy; Pascal Turlure; Norbert Vey; Christian Recher; Caroline Dartigeas; Laurence Legros; Jacques Delaunay; Sorin Visanica; Aspasia Stamatoullas; Pierre Fenaux; Lionel Adès
Journal:  Blood       Date:  2012-12-13       Impact factor: 22.113

3.  Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes.

Authors:  Felicitas Thol; Sofia Kade; Carola Schlarmann; Patrick Löffeld; Michael Morgan; Jürgen Krauter; Marcin W Wlodarski; Britta Kölking; Martin Wichmann; Kerstin Görlich; Gudrun Göhring; Gesine Bug; Oliver Ottmann; Charlotte M Niemeyer; Wolf-Karsten Hofmann; Brigitte Schlegelberger; Arnold Ganser; Michael Heuser
Journal:  Blood       Date:  2012-03-02       Impact factor: 22.113

4.  Revised international prognostic scoring system for myelodysplastic syndromes.

Authors:  Peter L Greenberg; Heinz Tuechler; Julie Schanz; Guillermo Sanz; Guillermo Garcia-Manero; Francesc Solé; John M Bennett; David Bowen; Pierre Fenaux; Francois Dreyfus; Hagop Kantarjian; Andrea Kuendgen; Alessandro Levis; Luca Malcovati; Mario Cazzola; Jaroslav Cermak; Christa Fonatsch; Michelle M Le Beau; Marilyn L Slovak; Otto Krieger; Michael Luebbert; Jaroslaw Maciejewski; Silvia M M Magalhaes; Yasushi Miyazaki; Michael Pfeilstöcker; Mikkael Sekeres; Wolfgang R Sperr; Reinhard Stauder; Sudhir Tauro; Peter Valent; Teresa Vallespi; Arjan A van de Loosdrecht; Ulrich Germing; Detlef Haase
Journal:  Blood       Date:  2012-06-27       Impact factor: 22.113

Review 5.  Allogeneic stem cell transplantation for elderly patients with myelodysplastic syndrome.

Authors:  Nicolaus Kröger
Journal:  Blood       Date:  2012-04-13       Impact factor: 22.113

6.  Incidence of 17p deletions and TP53 mutation in myelodysplastic syndrome and acute myeloid leukemia with 5q deletion.

Authors:  Amel Sebaa; Lionel Ades; Fanny Baran-Marzack; Marie-Joelle Mozziconacci; Dominique Penther; Sophie Dobbelstein; Aspasia Stamatoullas; Christian Récher; Thomas Prebet; Soraya Moulessehoul; Pierre Fenaux; Virginie Eclache
Journal:  Genes Chromosomes Cancer       Date:  2012-08-30       Impact factor: 5.006

7.  Age-related clonal hematopoiesis associated with adverse outcomes.

Authors:  Siddhartha Jaiswal; Pierre Fontanillas; Jason Flannick; Alisa Manning; Peter V Grauman; Brenton G Mar; R Coleman Lindsley; Craig H Mermel; Noel Burtt; Alejandro Chavez; John M Higgins; Vladislav Moltchanov; Frank C Kuo; Michael J Kluk; Brian Henderson; Leena Kinnunen; Heikki A Koistinen; Claes Ladenvall; Gad Getz; Adolfo Correa; Benjamin F Banahan; Stacey Gabriel; Sekar Kathiresan; Heather M Stringham; Mark I McCarthy; Michael Boehnke; Jaakko Tuomilehto; Christopher Haiman; Leif Groop; Gil Atzmon; James G Wilson; Donna Neuberg; David Altshuler; Benjamin L Ebert
Journal:  N Engl J Med       Date:  2014-11-26       Impact factor: 91.245

8.  Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B.

Authors:  Lewis R Silverman; Erin P Demakos; Bercedis L Peterson; Alice B Kornblith; Jimmie C Holland; Rosalie Odchimar-Reissig; Richard M Stone; Douglas Nelson; Bayard L Powell; Carlos M DeCastro; John Ellerton; Richard A Larson; Charles A Schiffer; James F Holland
Journal:  J Clin Oncol       Date:  2002-05-15       Impact factor: 44.544

9.  Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes.

Authors:  Rafael Bejar; Kristen E Stevenson; Bennett A Caughey; Omar Abdel-Wahab; David P Steensma; Naomi Galili; Azra Raza; Hagop Kantarjian; Ross L Levine; Donna Neuberg; Guillermo Garcia-Manero; Benjamin L Ebert
Journal:  J Clin Oncol       Date:  2012-08-06       Impact factor: 44.544

10.  ASXL1 and SETBP1 mutations and their prognostic contribution in chronic myelomonocytic leukemia: a two-center study of 466 patients.

Authors:  M M Patnaik; R Itzykson; T L Lasho; O Kosmider; C M Finke; C A Hanson; R A Knudson; R P Ketterling; A Tefferi; E Solary
Journal:  Leukemia       Date:  2014-04-03       Impact factor: 11.528

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  17 in total

1.  Antitumor synergy with SY-1425, a selective RARα agonist, and hypomethylating agents in retinoic acid receptor pathway activated models of acute myeloid leukemia.

Authors:  Michael R McKeown; Liv Johannessen; Emily Lee; Christopher Fiore; Emmanuelle di Tomaso
Journal:  Haematologica       Date:  2018-10-18       Impact factor: 9.941

2.  The clonal origins of leukemic progression of myelodysplasia.

Authors:  T Kim; M S Tyndel; H J Kim; J-S Ahn; S H Choi; H J Park; Y-K Kim; D-H Yang; J-J Lee; S-H Jung; S Y Kim; Y H Min; J-W Cheong; S K Sohn; J H Moon; M Choi; M Lee; Z Zhang; D D H Kim
Journal:  Leukemia       Date:  2017-01-16       Impact factor: 11.528

3.  Decitabine treatment sensitizes tumor cells to T-cell-mediated cytotoxicity in patients with myelodysplastic syndromes.

Authors:  Zheng Zhang; Qi He; Ying Tao; Juan Guo; Feng Xu; Ling-Yun Wu; You-Shan Zhao; Dong Wu; Li-Yu Zhou; Ji-Ying Su; Lu-Xi Song; Chao Xiao; Xiao Li; Chun-Kang Chang
Journal:  Am J Transl Res       Date:  2017-02-15       Impact factor: 4.060

Review 4.  Clinical Implications of Genetic Mutations in Myelodysplastic Syndrome.

Authors:  James A Kennedy; Benjamin L Ebert
Journal:  J Clin Oncol       Date:  2017-02-13       Impact factor: 44.544

Review 5.  Biology of the bone marrow microenvironment and myelodysplastic syndromes.

Authors:  Erinn B Rankin; Anupama Narla; Joseph K Park; Shuo Lin; Kathleen M Sakamoto
Journal:  Mol Genet Metab       Date:  2015-07-20       Impact factor: 4.797

6.  Time-dependent changes in mortality and transformation risk in MDS.

Authors:  Michael Pfeilstöcker; Heinz Tuechler; Guillermo Sanz; Julie Schanz; Guillermo Garcia-Manero; Francesc Solé; John M Bennett; David Bowen; Pierre Fenaux; Francois Dreyfus; Hagop Kantarjian; Andrea Kuendgen; Luca Malcovati; Mario Cazzola; Jaroslav Cermak; Christa Fonatsch; Michelle M Le Beau; Marilyn L Slovak; Alessandro Levis; Michael Luebbert; Jaroslaw Maciejewski; Sigrid Machherndl-Spandl; Silvia M M Magalhaes; Yasushi Miyazaki; Mikkael A Sekeres; Wolfgang R Sperr; Reinhard Stauder; Sudhir Tauro; Peter Valent; Teresa Vallespi; Arjan A van de Loosdrecht; Ulrich Germing; Detlef Haase; Peter L Greenberg
Journal:  Blood       Date:  2016-06-22       Impact factor: 22.113

7.  Scoring System Prognostic of Outcome in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndrome.

Authors:  Brian C Shaffer; Kwang Woo Ahn; Zhen-Huan Hu; Taiga Nishihori; Adriana K Malone; David Valcárcel; Michael R Grunwald; Ulrike Bacher; Betty Hamilton; Mohamed A Kharfan-Dabaja; Ayman Saad; Corey Cutler; Erica Warlick; Ran Reshef; Baldeep Mona Wirk; Mitchell Sabloff; Omotayo Fasan; Aaron Gerds; David Marks; Richard Olsson; William Allen Wood; Luciano J Costa; Alan M Miller; Jorge Cortes; Andrew Daly; Tamila L Kindwall-Keller; Rammurti Kamble; David A Rizzieri; Jean-Yves Cahn; Robert Peter Gale; Basem William; Mark Litzow; Peter H Wiernik; Jane Liesveld; Bipin N Savani; Ravi Vij; Celalettin Ustun; Edward Copelan; Uday Popat; Matt Kalaycio; Richard Maziarz; Edwin Alyea; Ron Sobecks; Steven Pavletic; Martin Tallman; Wael Saber
Journal:  J Clin Oncol       Date:  2016-04-04       Impact factor: 44.544

Review 8.  Myelodysplastic Syndromes Diagnosis: What Is the Role of Molecular Testing?

Authors:  Rafael Bejar
Journal:  Curr Hematol Malig Rep       Date:  2015-09       Impact factor: 3.952

9.  Distinct transcriptomic and exomic abnormalities within myelodysplastic syndrome marrow cells.

Authors:  Hogune Im; Varsha Rao; Kunju Sridhar; Jason Bentley; Tejaswini Mishra; Rui Chen; Jeff Hall; Armin Graber; Yan Zhang; Xiao Li; George I Mias; Michael P Snyder; Peter L Greenberg
Journal:  Leuk Lymphoma       Date:  2018-04-04

Review 10.  A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers.

Authors:  Jeannine Diesch; Anabel Zwick; Anne-Kathrin Garz; Anna Palau; Marcus Buschbeck; Katharina S Götze
Journal:  Clin Epigenetics       Date:  2016-06-21       Impact factor: 6.551

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