Literature DB >> 26210353

Biology of the bone marrow microenvironment and myelodysplastic syndromes.

Erinn B Rankin1, Anupama Narla2, Joseph K Park2, Shuo Lin3, Kathleen M Sakamoto4.   

Abstract

Myelodysplastic syndromes (MDS) are characterized by cytopenias resulting from ineffective hematopoiesis with a predisposition to transform to acute myeloid leukemia (AML). Recent evidence suggests that the hematopoietic stem cell microenvironment contributes to the pathogenesis of MDS. Inflammation and hypoxia within the bone marrow are key regulators of hematopoietic stem and progenitor cells that can lead to several bone marrow failure syndromes, including MDS. In this brief review, we provide an overview of the clinical and molecular features of MDS, the bone marrow microenvironment, and specific pathways that lead to abnormal blood cell development in MDS. Characterization of key steps in the pathogenesis of MDS will lead to new approaches to treat patients with this disease.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Bone marrow microenvironment; Hypoxia; Inflammation; Myelodysplastic syndromes; Ribosomal deficiency; Signaling pathways

Mesh：

Year:  2015        PMID： 26210353      PMCID： PMC4618471          DOI： 10.1016/j.ymgme.2015.07.004

Source DB:  PubMed          Journal:  Mol Genet Metab        ISSN： 1096-7192            Impact factor:   4.797


  63 in total

1.  Modeling pO(2) distributions in the bone marrow hematopoietic compartment. II. Modified Kroghian models.

Authors:  D C Chow; L A Wenning; W M Miller; E T Papoutsakis
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2.  Malignancies and survival patterns in the National Cancer Institute inherited bone marrow failure syndromes cohort study.

Authors:  Blanche P Alter; Neelam Giri; Sharon A Savage; June A Peters; Jennifer T Loud; Lisa Leathwood; Ann G Carr; Mark H Greene; Philip S Rosenberg
Journal:  Br J Haematol       Date:  2010-04-30       Impact factor: 6.998

3.  Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors.

Authors:  Tony A Navas; Mani Mohindru; Myka Estes; Jing Ying Ma; Lubomir Sokol; Perry Pahanish; Simrit Parmar; Edwin Haghnazari; Li Zhou; Robert Collins; Irene Kerr; Aaron N Nguyen; Yin Xu; Leonidas C Platanias; Alan A List; Linda S Higgins; Amit Verma
Journal:  Blood       Date:  2006-08-29       Impact factor: 22.113

Review 4.  A central role for hypoxic signaling in cartilage, bone, and hematopoiesis.

Authors:  Erinn B Rankin; Amato J Giaccia; Ernestina Schipani
Journal:  Curr Osteoporos Rep       Date:  2011-06       Impact factor: 5.096

5.  Enhanced growth of myelodysplastic colonies in hypoxic conditions.

Authors:  James Edwin Thompson; Joseph Patrick Conlon; Xiaowei Yang; Patricia Vanessa Sanchez; Martin Carroll
Journal:  Exp Hematol       Date:  2007-01       Impact factor: 3.084

6.  Polymorphisms of IL-10 affect the severity and prognosis of myelodysplastic syndrome.

Authors:  Tetsuhiro Kasamatsu; Takayuki Saitoh; Yusuke Minato; Hiroaki Shimizu; Akihiko Yokohama; Norifumi Tsukamoto; Hiroshi Handa; Toru Sakura; Hirokazu Murakami
Journal:  Eur J Haematol       Date:  2015-05-26       Impact factor: 2.997

7.  Shwachman-Diamond syndrome: An inherited preleukemic bone marrow failure disorder with aberrant hematopoietic progenitors and faulty marrow microenvironment.

Authors:  Y Dror; M H Freedman
Journal:  Blood       Date:  1999-11-01       Impact factor: 22.113

8.  BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin.

Authors:  Matthias Mayerhofer; Peter Valent; Wolfgang R Sperr; James D Griffin; Christian Sillaber
Journal:  Blood       Date:  2002-07-18       Impact factor: 22.113

9.  Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance.

Authors:  Amelie V Guitart; Chithra Subramani; Alejandro Armesilla-Diaz; Gillian Smith; Catarina Sepulveda; Deniz Gezer; Milica Vukovic; Karen Dunn; Patrick Pollard; Tessa L Holyoake; Tariq Enver; Peter J Ratcliffe; Kamil R Kranc
Journal:  Blood       Date:  2013-07-26       Impact factor: 22.113

10.  Important genes in the pathogenesis of 5q- syndrome and their connection with ribosomal stress and the innate immune system pathway.

Authors:  Ota Fuchs
Journal:  Leuk Res Treatment       Date:  2012-02-13
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  11 in total

Review 1.  Nanotherapeutics for multiple myeloma.

Authors:  Alexander Zheleznyak; Monica Shokeen; Samuel Achilefu
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2018-04-26

2.  Combinatorial Efficacy of Quercitin and Nanoliposomal Ceramide for Acute Myeloid Leukemia.

Authors:  Colin M McGill; Timothy J Brown; Lindsey N Fisher; Sally J Gustafson; Kriya L Dunlap; Adam J Beck; Paul T Toran; David F Claxton; Brian M Barth
Journal:  Int J Biopharm Sci       Date:  2018-01-31

3.  Clofarabine versus fludarabine-based reduced-intensity conditioning regimen prior to allogeneic transplantation in adults with AML/MDS.

Authors:  Patrice Chevallier; Myriam Labopin; Regis Peffault de La Tour; Bruno Lioure; Claude-Eric Bulabois; Anne Huynh; Didier Blaise; Pascal Turlure; Etienne Daguindau; Natacha Maillard; Ibrahim Yakoub-Agha; Gaelle Guillerm; Jeremy Delage; Nathalie Contentin; Jacques-Olivier Bay; Florence Beckerich; Jean-Henri Bourhis; Marie Detrait; Stéphane Vigouroux; Sylvie François; Faezeh Legrand; Thierry Guillaume; Mohamad Mohty
Journal:  Cancer Med       Date:  2016-10-17       Impact factor: 4.452

4.  De novo AML exhibits greater microenvironment dysregulation compared to AML with myelodysplasia-related changes.

Authors:  Matheus Rodrigues Lopes; João Kleber Novais Pereira; Paula de Melo Campos; João Agostinho Machado-Neto; Fabiola Traina; Sara T Olalla Saad; Patricia Favaro
Journal:  Sci Rep       Date:  2017-01-13       Impact factor: 4.379

5.  Severe hypoxia selects hematopoietic progenitors with stem cell potential from primary Myelodysplastic syndrome bone marrow cell cultures.

Authors:  Erico Masala; Ana Valencia-Martinez; Serena Pillozzi; Tommaso Rondelli; Alice Brogi; Alessandro Sanna; Antonella Gozzini; Annarosa Arcangeli; Persio Dello Sbarba; Valeria Santini
Journal:  Oncotarget       Date:  2018-01-24

6.  Increased Reactive Oxygen Species and Cell Cycle Defects Contribute to Anemia in the RASA3 Mutant Mouse Model scat.

Authors:  Emily S Hartman; Elena C Brindley; Julien Papoin; Steven L Ciciotte; Yue Zhao; Luanne L Peters; Lionel Blanc
Journal:  Front Physiol       Date:  2018-06-05       Impact factor: 4.566

7.  Screening differentially expressed proteins from co-cultured hematopoietic cells and bone marrow-derived stromal cells by quantitative proteomics (SILAC) method.

Authors:  Rui Liu; Yi Wang; Bingxin Li; Hui Wang; Feng Guan; Zengqi Tan; Xiang Li
Journal:  Clin Proteomics       Date:  2019-07-18       Impact factor: 3.988

8.  Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis.

Authors:  Kelly M Arcipowski; Marinka Bulic; Sandeep Gurbuxani; Jonathan D Licht
Journal:  PLoS One       Date:  2016-09-09       Impact factor: 3.240

9.  Analysis of bone marrow supernatant neutrophil gelatinase-associated lipocalin and hematological parameters in hematological malignancy.

Authors:  Chi-Hyun Cho; Jaehyung Cha; Eun-Ah Chang; Myung-Hyun Nam; Seo-Jin Park; Hwa Jung Sung; Se Ryeon Lee
Journal:  J Clin Lab Anal       Date:  2020-02-24       Impact factor: 2.352

10.  Orthogonal targeting of osteoclasts and myeloma cells for radionuclide stimulated dynamic therapy induces multidimensional cell death pathways.

Authors:  Alexander Zheleznyak; Matthew Mixdorf; Lynne Marsala; Julie Prior; Xiaoxia Yang; Grace Cui; Baogang Xu; Steven Fletcher; Francesca Fontana; Gregory Lanza; Samuel Achilefu
Journal:  Theranostics       Date:  2021-06-22       Impact factor: 11.556
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