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Literature DB >> 2573279

The human chromogranin A gene: chromosome assignment and RFLP analysis.

W S Modi¹, M A Levine, H N Seuanez, M Dean, S J O'Brien.

Abstract

Chromogranin A/secretory protein I (CgA) is a glycoprotein that is stored and released along with peptide hormones and neurotransmitters from several tissues, although its exact function is not known. A cDNA (gene symbol CHGA) clone was used as a probe in Southern blot analyses of human-rodent somatic cell hybrid DNAs. Discordancy analysis allowed confirmation of the assignment of the gene to chromosome 14. These results were extended using in situ chromosome hybridization, and a signal was found at 14q32. BglII digestion of genomic DNA from 28 unrelated Caucasian individuals probed with CHGA detected a two-allele RFLP with allelic frequencies of .34 and .66.

Entities: Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2573279 PMCID： PMC1683438

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

19 in total

1. Acetylation of chromosome squashes of Drosophila melanogaster decreases the background in autoradiographs from hybridization with [125I]-labeled RNA.

Authors: S Hayashi; I C Gillam; A D Delaney; G M Tener
Journal: J Histochem Cytochem Date: 1978-08 Impact factor: 2.479

2. Immunological identification and characterization of chromogranins coded by poly(A) mRNA from bovine adrenal medulla and pituitary gland and human phaeochromocytoma.

Authors: G Serck-Hanssen; D T O'Connor
Journal: J Biol Chem Date: 1984-09-25 Impact factor: 5.157

Review 3. The composition of adrenal chromaffin granules: an assessment of controversial results.

Authors: H Winkler
Journal: Neuroscience Date: 1976 Impact factor: 3.590

4. Strategies for detecting and characterizing restriction fragment length polymorphisms (RFLP's).

Authors: M H Skolnick; R White
Journal: Cytogenet Cell Genet Date: 1982

5. The human calcitonin gene is located on the short arm of chromosome 11.

Authors: D Przepiorka; S B Baylin; O W McBride; J R Testa; A de Bustros; B D Nelkin
Journal: Biochem Biophys Res Commun Date: 1984-04-30 Impact factor: 3.575

6. Similarity of secretory protein I from parathyroid gland to chromogranin A from adrenal medulla.

Authors: D V Cohn; R Zangerle; R Fischer-Colbrie; L L Chu; J J Elting; J W Hamilton; H Winkler
Journal: Proc Natl Acad Sci U S A Date: 1982-10 Impact factor: 11.205

7. Dispersion of the ras family of transforming genes to four different chromosomes in man.

Authors: S J O'Brien; W G Nash; J L Goodwin; D R Lowy; E H Chang
Journal: Nature Date: 1983-04-28 Impact factor: 49.962

8. Cellular and cell-free processing of parathyroid secretory proteins.

Authors: J A Majzoub; P C Dee; J F Habener
Journal: J Biol Chem Date: 1982-04-10 Impact factor: 5.157

9. Bovine chromogranin A sequence and distribution of its messenger RNA in endocrine tissues.

Authors: A Iacangelo; H U Affolter; L E Eiden; E Herbert; M Grimes
Journal: Nature Date: 1986 Sep 4-10 Impact factor: 49.962

10. The gene for human chromogranin A (CgA) is located on chromosome 14.

Authors: S S Murray; L L Deaven; D W Burton; D I O'Connor; P L Mellon; L J Deftos
Journal: Biochem Biophys Res Commun Date: 1987-01-15 Impact factor: 3.575

4 in total

1. Cell type-specific gene expression in the neuroendocrine system. A neuroendocrine-specific regulatory element in the promoter of chromogranin A, a ubiquitous secretory granule core protein.

Authors: H Wu; D J Rozansky; N J Webster; D T O'Connor
Journal: J Clin Invest Date: 1994-07 Impact factor: 14.808