Literature DB >> 25731019

[The virulence factors of Mycobacterium tuberculosis: genetic control, new conceptions].

A A Prozorov, I A Fedorova, O B Bekker, V N Danilenko.   

Abstract

The problem of Mycobacterium tuberculosis virulence, together with drug resistance, is becoming key for the design of drugs with a new mechanism of action and the production of modern concepts and tuberculosis treatment schemes. The review describes gene complexes and their products, including mycolic acids and global regulatory systems at the level of transcriptional, translational, and post-translational modification, etc. The criteria for selection of virulence/pathogenicity factors that might be used for comparative genomic analysis of strains differing in the degree of virulence were recommended. The experimental approaches and test systems for an adequate estimation of the virulence degree of different strains of M. tuberculosis were analyzed.

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Year:  2014        PMID： 25731019

Source DB:  PubMed          Journal:  Genetika        ISSN： 0016-6758


  10 in total

1.  Draft genome sequence of Mycobacterium tuberculosis strain B9741 of Beijing B0/W lineage from HIV positive patient from Siberia.

Authors:  K V Shur; M V Zaychikova; N E Mikheecheva; K M Klimina; O B Bekker; S N Zhdanova; O B Ogarkov; V N Danilenko
Journal:  Genom Data       Date:  2016-08-03

2.  Correlates between models of virulence for Mycobacterium tuberculosis among isolates of the Central Asian lineage: a case for lysozyme resistance testing?

Authors:  Claire Pardieu; Nicola Casali; Simon O Clark; Richard Hooper; Ann Williams; Preya Velji; Ximena Gonzalo; Francis Drobniewski
Journal:  Infect Immun       Date:  2015-03-16       Impact factor: 3.441

3.  Role of C-terminal domain of Mycobacterium tuberculosis PE6 (Rv0335c) protein in host mitochondrial stress and macrophage apoptosis.

Authors:  Parul Bhatt; Sadhna Sharma; Monika Sharma
Journal:  Apoptosis       Date:  2022-10-18       Impact factor: 5.561

4.  Mycobacterium tuberculosis Type II Toxin-Antitoxin Systems: Genetic Polymorphisms and Functional Properties and the Possibility of Their Use for Genotyping.

Authors:  Marina V Zaychikova; Natalia V Zakharevich; Maria O Sagaidak; Nadezhda A Bogolubova; Tatiana G Smirnova; Sofya N Andreevskaya; Elena E Larionova; Maria G Alekseeva; Larisa N Chernousova; Valery N Danilenko
Journal:  PLoS One       Date:  2015-12-14       Impact factor: 3.240

5.  A Nonsynonymous SNP Catalog of Mycobacterium tuberculosis Virulence Genes and Its Use for Detecting New Potentially Virulent Sublineages.

Authors:  Natalya E Mikheecheva; Marina V Zaychikova; Alexander V Melerzanov; Valery N Danilenko
Journal:  Genome Biol Evol       Date:  2017-04-01       Impact factor: 3.416

6.  Patterns and processes of Mycobacterium bovis evolution revealed by phylogenomic analyses.

Authors:  José S L Patané; Joaquim Martins; Ana Beatriz Castelão; Christiane Nishibe; Luciana Montera; Fabiana Bigi; Martin J Zumárraga; Angel A Cataldi; Antônio Fonseca Junior; Eliana Roxo; Ana Luiza; A R Osório; Kláudia S Jorge Ufms; Tyler C Thacker; Nalvo F Almeida; Flabio R Araújo; João C Setubal
Journal:  Genome Biol Evol       Date:  2017-02-13       Impact factor: 3.416

7.  Virulence of Mycobacterium tuberculosis Clinical Isolates Is Associated With Sputum Pre-treatment Bacterial Load, Lineage, Survival in Macrophages, and Cytokine Response.

Authors:  Trinh T B Tram; Hoang N Nhung; Srinivasan Vijay; Hoang T Hai; Do D A Thu; Vu T N Ha; Tran D Dinh; Philip M Ashton; Nguyen T Hanh; Nguyen H Phu; Guy E Thwaites; Nguyen T T Thuong
Journal:  Front Cell Infect Microbiol       Date:  2018-11-27       Impact factor: 5.293

8.  Sequencing and Analysis of Three Mycobacterium tuberculosis Genomes of the B0/N-90 Sublineage.

Authors:  Natalia V Zakharevich; Marina V Zaychikova; Kirill V Shur; Olga B Bekker; Dmitry A Maslov; Valery N Danilenko
Journal:  Microbiol Resour Announc       Date:  2019-09-26

9.  Draft Genome Sequences of Mycobacterium tuberculosis Clinical Isolates from the Ural Region of Russia That Carry the pks15/1 Gene.

Authors:  Kirill V Shur; Natalia V Zakharevich; Natalia I Akimova; Roman A Yunes; Svetlana G Frolova; Dmitry A Maslov; Valery N Danilenko
Journal:  Microbiol Resour Announc       Date:  2019-12-05

10.  Draft Genome Sequence of Mycobacterium tuberculosis Strain E186hv of Beijing B0/W Lineage with Reduced Virulence.

Authors:  K V Shur; K M Klimina; N V Zakharevich; D A Maslov; O B Bekker; M V Zaychikova; E Y Kamaev; M A Kravchenko; S N Skornyakov; Y Zhang; V N Danilenko
Journal:  Genome Announc       Date:  2015-05-07
  10 in total

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