| Literature DB >> 2572846 |
F Spyratos1, T Maudelonde, J P Brouillet, M Brunet, A Defrenne, C Andrieu, K Hacene, A Desplaces, J Rouëssé, H Rochefort.
Abstract
122 patients with primary breast cancer were followed-up for a median of 4.6 years after surgery. The concentration of cathepsin D in tumour cytosol was strongly related to both metastasis-free survival and disease-free survival and was independent of nine conventional prognostic indices. Cathepsin D assay may prove particularly useful in identifying women who, though without lymph node involvement at presentation, are at high risk of metastatic disease.Entities:
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Year: 1989 PMID： 2572846 DOI： 10.1016/s0140-6736(89)91487-6
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321