Literature DB >> 25433507

Post-operative nomogram for predicting freedom from recurrence after surgery in localised breast cancer receiving adjuvant hormone therapy.

Chafika Mazouni1, Frédéric Fina, Sylvie Romain, Pascal Bonnier, L'houcine Ouafik, Pierre-Marie Martin.   

Abstract

PURPOSE: To develop a prognostic nomogram to predict freedom from recurrence for patients treated with adjuvant hormonal therapy (HT) for localised breast cancer (BC).
METHODS: We performed a retrospective analysis of 142 patients treated with adjuvant HT between 1996 and 2000. Clinical and pathological parameters were analysed.
RESULTS: A nomogram that predicts the probability of remaining free of recurrence for 5 years after surgery with adjuvant HT was developed using a Cox proportional hazards regression model. The progesterone receptor status (p < 0.001), nodal status (p = 0.008) and cathepsin-D (p < 0.001) were retained to construct the nomogram (C-index 0.734).
CONCLUSIONS: The nomogram we developed may be useful for estimating the probability of successful treatment 5 years after surgery for localised BC.

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Year:  2014        PMID: 25433507     DOI: 10.1007/s00432-014-1889-7

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN: 0171-5216            Impact factor:   4.553


  40 in total

1.  Cathepsin D: an independent prognostic factor for metastasis of breast cancer.

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10.  A prediction model for breast cancer recurrence after adjuvant hormone therapy.

Authors:  P Boracchi; D Coradini; S Antolini; S Oriana; R Dittadi; M Gion; M G Daidone; E Biganzoli
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