| Literature DB >> 25728208 |
J S Biswas1, A Patel1, J A Otter1, P Wade1, W Newsholme1, E van Kleef2, S D Goldenberg3.
Abstract
Fidaxomicin is sporicidal and may be associated with a reduced time to resolution of diarrhoea when used to treat patients with Clostridium difficile infection (CDI). This study investigated whether fidaxomicin for treatment of all patients with CDI reduced C. difficile environmental contamination. Surfaces in the rooms of 66 hospitalized patients treated with metronidazole and/or vancomycin and 68 hospitalized patients treated with fidaxomicin were sampled. Patients treated with fidaxomicin were less likely to contaminate their environment (25/68, 36.8%) than patients treated with metronidazole and/or vancomycin (38/66 57.6%) (P = 0.02). Treatment with fidaxomicin was associated with reduced environmental contamination with C. difficile.Entities:
Keywords: Clostridium difficile; Contamination; Environment; Fidaxomicin
Mesh：
Substances：
Year: 2015 PMID： 25728208 DOI： 10.1016/j.jhin.2015.01.015
Source DB: PubMed Journal: J Hosp Infect ISSN： 0195-6701 Impact factor: 3.926