C P Rodda1,2,3, J E Benson4, A J Vincent5,6, C L Whitehead7, A Polykov8,9, B Vollenhoven10,11. 1. Department of Paediatrics, University of Melbourne, Parkville, Vic., Australia. 2. Department of Paediatrics, Monash University, Clayton, Vic., Australia. 3. Paediatric Department, Sunshine Hospital, St Albans, Vic., Australia. 4. Department of Obstetrics and Gynaecology, Barwon Health, Geelong, Vic., Australia. 5. Monash Centre for Health Research and Implementation, School of Public Health and Preventative Medicine, Monash University, Clayton, Vic., Australia. 6. Clinical Nutrition and Metabolism Unit, Monash Health, Clayton, Vic., Australia. 7. Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Vic., Australia. 8. Reproductive Biology Unit, Royal Women's Hospital, Parkville, Vic., Australia. 9. Melbourne IVF, East Melbourne, Vic., Australia. 10. Department of Obstetrics and Gynaecology, Monash University, Clayton, Vic., Australia. 11. Gynaecology Unit, Monash Health, Clayton, Vic., Australia.
Abstract
OBJECTIVE: To determine whether maternal vitamin D supplementation, in the vitamin D deficient mother, prevents neonatal vitamin D deficiency. DESIGN: Open-label randomized controlled trial. SETTING:Metropolitan Melbourne, Australia, tertiary hospital routine antenatal outpatient clinic. PARTICIPANTS: Seventy-eight women with singleton pregnancies with vitamin D deficiency/insufficiency (serum 25-OH Vit D < 75 nmol/l) at their first antenatal appointment at 12-16-week gestation were recruited. INTERVENTION: Participants were randomized to vitamin D supplementation (2000-4000 IU cholecalciferol) orally daily until delivery or no supplementation. MAIN OUTCOME MEASURES: The primary outcome was neonatal serum 25-OH vit D concentration at delivery. The secondary outcome was maternal serum 25-OH vit D concentration at delivery. RESULTS:Baseline mean maternal serum 25-OH vit D concentrations were similar (P = 0·9) between treatment (32 nmol/l, 95% confidence interval 26-39 nmol/l) and control groups (33 nmol/l, 95% CI 26-39 nmol/l). Umbilical cord serum 25-OH vit D concentrations at delivery were higher (P < 0·0001) in neonates of treatment group mothers (81 nmol/l, 95% CI; 70-91 nmol/l) compared with neonates of control group mothers (42 nmol/l, 95% CI; 34-50 nmol/l) with a strongly positive correlation between maternal serum 25-OH Vit D and umbilical cord serum 25-OH vit D concentrations at delivery (Spearman rank correlation coefficient 0·88; P < 0·0001). Mean maternal serum 25-OH Vit D concentrations at delivery were higher (P < 0·0001) in the treatment group (71 nmol/l, 95% CI; 62-81 nmol/l) compared with the control group (36 nmol/l, 95% CI; 29-42 nmol/l). CONCLUSION:Vitamin D supplementation of vitamin Ddeficient pregnant women prevents neonatal vitamin D deficiency.
RCT Entities:
OBJECTIVE: To determine whether maternal vitamin D supplementation, in the vitamin D deficient mother, prevents neonatal vitamin D deficiency. DESIGN: Open-label randomized controlled trial. SETTING: Metropolitan Melbourne, Australia, tertiary hospital routine antenatal outpatient clinic. PARTICIPANTS: Seventy-eight women with singleton pregnancies with vitamin Ddeficiency/insufficiency (serum 25-OH Vit D < 75 nmol/l) at their first antenatal appointment at 12-16-week gestation were recruited. INTERVENTION: Participants were randomized to vitamin D supplementation (2000-4000 IU cholecalciferol) orally daily until delivery or no supplementation. MAIN OUTCOME MEASURES: The primary outcome was neonatal serum 25-OH vit D concentration at delivery. The secondary outcome was maternal serum 25-OH vit D concentration at delivery. RESULTS: Baseline mean maternal serum 25-OH vit D concentrations were similar (P = 0·9) between treatment (32 nmol/l, 95% confidence interval 26-39 nmol/l) and control groups (33 nmol/l, 95% CI 26-39 nmol/l). Umbilical cord serum 25-OH vit D concentrations at delivery were higher (P < 0·0001) in neonates of treatment group mothers (81 nmol/l, 95% CI; 70-91 nmol/l) compared with neonates of control group mothers (42 nmol/l, 95% CI; 34-50 nmol/l) with a strongly positive correlation between maternal serum 25-OH Vit D and umbilical cord serum 25-OH vit D concentrations at delivery (Spearman rank correlation coefficient 0·88; P < 0·0001). Mean maternal serum 25-OH Vit D concentrations at delivery were higher (P < 0·0001) in the treatment group (71 nmol/l, 95% CI; 62-81 nmol/l) compared with the control group (36 nmol/l, 95% CI; 29-42 nmol/l). CONCLUSION:Vitamin D supplementation of vitamin D deficient pregnant women prevents neonatal vitamin D deficiency.
Authors: Michela Traglia; Gayle C Windham; Michelle Pearl; Victor Poon; Darryl Eyles; Karen L Jones; Kristen Lyall; Martin Kharrazi; Lisa A Croen; Lauren A Weiss Journal: Genetics Date: 2020-02-11 Impact factor: 4.562
Authors: Paula Guedes Cocate; Gilberto Kac; Berit L Heitmann; Paulo Nadanovsky; Maria Cláudia da Veiga Soares Carvalho; Camila Benaim; Michael Maia Schlüssel; Maria Beatriz Trindade de Castro; Nadya Helena Alves-Santos; Amanda Farnum Baptista; Michael F Holick; Rana R Mokhtar; Alessandra Raymundo Bomfim; Amanda Rodrigues Amorim Adegboye Journal: Pilot Feasibility Stud Date: 2019-03-05