Literature DB >> 2572333

Studies on antiallergy agents. III. Synthesis of 2-anilino-1,6-dihydro-6-oxo-5-pyrimidinecarboxylic acids and related compounds.

K Ozeki, T Ichikawa, H Takehara, K Tanimura, M Sato, H Yaginuma.   

Abstract

A series of 2-anilino-1,6-dihydro-6-oxo-5-pyrimidinecarboxylic acids with various substituents was synthesized and evaluated in the rat passive cutaneous anaphylaxis test for antiallergic activity. High activity by intraperitoneal and oral administrations was observed for the 3-trifluoromethyl and 2-alkoxyanilino derivatives (64, 79, 81, 82 and 85). Structure-activity relationships are discussed.

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Year:  1989        PMID： 2572333     DOI： 10.1248/cpb.37.1780

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  3 in total

1.  Androgen receptor antagonists and anti-prostate cancer activities of some newly synthesized substituted fused pyrazolo-, triazolo- and thiazolo-pyrimidine derivatives.

Authors:  Saleh A Bahashwan; Ahmed A Fayed; Mohamed A Ramadan; Abd El-Galil E Amr; Naif O Al-Harbi
Journal:  Int J Mol Sci       Date:  2014-11-24       Impact factor: 5.923

2.  Discovery of an algicidal compound from Brevibacterium sp. BS01 and its effect on a harmful algal bloom-causing species, Alexandrium tamarense.

Authors:  Xinli An; Bangzhou Zhang; Huajun Zhang; Yi Li; Wei Zheng; Zhiming Yu; Lijun Fu; Tianling Zheng
Journal:  Front Microbiol       Date:  2015-11-05       Impact factor: 5.640

3.  Synthesis, Reactions and Evaluation of the Antimicrobial Activity of Some 4-(p-Halophenyl)-4H-naphthopyran, Pyranopyrimidine and Pyranotriazolopyrimidine Derivatives.

Authors:  Ashraf H F Abd El-Wahab
Journal:  Pharmaceuticals (Basel)       Date:  2012-07-12
  3 in total

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