BACKGROUND: Little is known about population-based maternal, child, and system characteristics associated with high hospital resource use for children with orofacial clefts (OFC) in the US. METHODS: This was a statewide, population-based, retrospective observational study of children with OFC born between 1998 and 2006, identified by the Florida Birth Defects Registry whose records were linked with longitudinal hospital discharge records. We stratified the descriptive results by cleft type [cleft lip with cleft palate, cleft lip, and cleft palate] and by isolated versus nonisolated OFC (accompanied by other coded major birth defects). We used Poisson regression to analyze associations between selected characteristics and high hospital resource use (≥90th percentile of estimated hospitalized days and inpatient costs) for birth, postbirth, and total hospitalizations initiated before age 2 years. RESULTS: Our analysis included 2,129 children with OFC. Infants who were born low birth weight (<2500 grams) were significantly more likely to have high birth hospitalization costs for CLP (adjusted prevalence ratio: 1.6 [95% confidence interval: 1.0-2.7]), CL (adjusted prevalence ratio: 3.0 [95% confidence interval: 1.1-8.1]), and CP (adjusted prevalence ratio: 2.3 [95% confidence interval: 1.3-4.0]). Presence of multiple birth defects was significantly associated with a three- to eleven-fold and a three- to nine-fold increase in the prevalence of high costs and number of hospitalized days, respectively; at birth, postbirth before age 2 years and overall hospitalizations. CONCLUSION: Children with cleft palate had the greatest hospital resources use. Additionally, the presence of multiple birth defects contributed to greater inpatient days and costs for children with OFC.
BACKGROUND: Little is known about population-based maternal, child, and system characteristics associated with high hospital resource use for children with orofacial clefts (OFC) in the US. METHODS: This was a statewide, population-based, retrospective observational study of children with OFC born between 1998 and 2006, identified by the Florida Birth Defects Registry whose records were linked with longitudinal hospital discharge records. We stratified the descriptive results by cleft type [cleft lip with cleft palate, cleft lip, and cleft palate] and by isolated versus nonisolated OFC (accompanied by other coded major birth defects). We used Poisson regression to analyze associations between selected characteristics and high hospital resource use (≥90th percentile of estimated hospitalized days and inpatient costs) for birth, postbirth, and total hospitalizations initiated before age 2 years. RESULTS: Our analysis included 2,129 children with OFC. Infants who were born low birth weight (<2500 grams) were significantly more likely to have high birth hospitalization costs for CLP (adjusted prevalence ratio: 1.6 [95% confidence interval: 1.0-2.7]), CL (adjusted prevalence ratio: 3.0 [95% confidence interval: 1.1-8.1]), and CP (adjusted prevalence ratio: 2.3 [95% confidence interval: 1.3-4.0]). Presence of multiple birth defects was significantly associated with a three- to eleven-fold and a three- to nine-fold increase in the prevalence of high costs and number of hospitalized days, respectively; at birth, postbirth before age 2 years and overall hospitalizations. CONCLUSION:Children with cleft palate had the greatest hospital resources use. Additionally, the presence of multiple birth defects contributed to greater inpatient days and costs for children with OFC.
Authors: Cara T Mai; Cynthia H Cassell; Robert E Meyer; Jennifer Isenburg; Mark A Canfield; Russel Rickard; Richard S Olney; Erin B Stallings; Meredith Beck; S Shahrukh Hashmi; Sook Ja Cho; Russell S Kirby Journal: Birth Defects Res A Clin Mol Teratol Date: 2014-11-14
Authors: Jason L Salemi; Kimberlea W Hauser; Jean Paul Tanner; Diana Sampat; Jane A Correia; Sharon M Watkins; Russell S Kirby Journal: J Registry Manag Date: 2010
Authors: James M Robbins; Peter Damiano; Charlotte M Druschel; Charlotte A Hobbs; Paul A Romitti; April A Austin; Margaret Tyler; J Alex Reading; Whitney Burnett Journal: Cleft Palate Craniofac J Date: 2010-09
Authors: Judith Weiss; Milton Kotelchuck; Scott D Grosse; Susan E Manning; Marlene Anderka; Diego F Wyszynski; Howard Cabral; Wanda Barfield; Raul Garcia; Emily Lu; Cathy Higgins Journal: Birth Defects Res A Clin Mol Teratol Date: 2009-11
Authors: Christine Nguyen; Tina Hernandez-Boussard; Sheryl M Davies; Jay Bhattacharya; Rohit K Khosla; Catherine M Curtin Journal: Cleft Palate Craniofac J Date: 2013-09-24
Authors: Joyce A Martin; Brady E Hamilton; Stephanie J Ventura; Michelle J K Osterman; Elizabeth C Wilson; T J Mathews Journal: Natl Vital Stat Rep Date: 2012-08-28
Authors: Kristin D Pfeifauf; Kamlesh B Patel; Alison Snyder-Warwick; Gary B Skolnick; Sibyl Scheve; Sybill D Naidoo Journal: Cleft Palate Craniofac J Date: 2018-05-21
Authors: Nelangi M Pinto; Richard Nelson; Lorenzo Botto; Michael D Puchalski; Sergey Krikov; Jaewhan Kim; Norman J Waitzman Journal: Birth Defects Res Date: 2017-02-13 Impact factor: 2.344