Literature DB >> 25721328

Transcription factors and chromatin proteins as therapeutic targets in cancer.

Simon J Johnston1, Jason S Carroll2.   

Abstract

Targeting the factors that regulate gene transcription is a compelling strategy in cancer therapeutics. Traditionally, these have been considered intractable targets, but recent work has revealed novel strategies for the regulation of transcription factor activity in cancer. This review will highlight some of the emerging concepts and provide examples where agents that target transcription factors are being exploited clinically for cancer therapies.
Copyright © 2015. Published by Elsevier B.V.

Entities:  

Keywords:  Cancer; Drugs; Nuclear receptors; Small molecules; Transcription factors; siRNA

Mesh：

Substances：

Year:  2015        PMID： 25721328     DOI： 10.1016/j.bbcan.2015.02.002

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  13 in total

1.  Small molecule-based targeting of TTD-A dimerization to control TFIIH transcriptional activity represents a potential strategy for anticancer therapy.

Authors:  Virginie Gervais; Isabelle Muller; Pierre-Olivier Mari; Amandine Mourcet; Kumar Tekwani Movellan; Pascal Ramos; Julien Marcoux; Valérie Guillet; Sumaira Javaid; Odile Burlet-Schiltz; Georges Czaplicki; Alain Milon; Giuseppina Giglia-Mari
Journal:  J Biol Chem       Date:  2018-08-01       Impact factor: 5.157

Review 2.  Cell fate control by pioneer transcription factors.

Authors:  Makiko Iwafuchi-Doi; Kenneth S Zaret
Journal:  Development       Date:  2016-06-01       Impact factor: 6.868

Review 3.  Therapeutic potential of HIV-1 entry inhibitor peptidomimetics.

Authors:  Nneka Pu Korie; Kwesi Z Tandoh; Samuel K Kwofie; Osbourne Quaye
Journal:  Exp Biol Med (Maywood)       Date:  2021-02-17

Review 4.  Suppression of chronic inflammation with engineered nanomaterials delivering nuclear factor κB transcription factor decoy oligodeoxynucleotides.

Authors:  Leila Farahmand; Behrad Darvishi; Keivan Majidzadeh-A
Journal:  Drug Deliv       Date:  2017-11       Impact factor: 6.419

Review 5.  Silencing the roadblocks to effective triple-negative breast cancer treatments by siRNA nanoparticles.

Authors:  Jenny G Parvani; Mark W Jackson
Journal:  Endocr Relat Cancer       Date:  2017-02-01       Impact factor: 5.900

6.  Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.

Authors:  Huabo Wang; Peter Teriete; Angela Hu; Dhanya Raveendra-Panickar; Kelsey Pendelton; John S Lazo; Julie Eiseman; Toril Holien; Kristine Misund; Ganna Oliynyk; Marie Arsenian-Henriksson; Nicholas D P Cosford; Anders Sundan; Edward V Prochownik
Journal:  Oncotarget       Date:  2015-10-20

7.  Survivin a radiogenetic promoter for glioblastoma viral gene therapy independently from CArG motifs.

Authors:  George E Naoum; Zeng B Zhu; Donald J Buchsbaum; David T Curiel; Waleed O Arafat
Journal:  Clin Transl Med       Date:  2017-03-01

8.  A screen for Fli-1 transcriptional modulators identifies PKC agonists that induce erythroid to megakaryocytic differentiation and suppress leukemogenesis.

Authors:  Tangjingjun Liu; Yao Yao; Gang Zhang; Ye Wang; Bin Deng; Jialei Song; Xiaogang Li; Fei Han; Xiao Xiao; Jue Yang; Lei Xia; You-Jun Li; Maksym Plachynta; Mu Zhang; Chen Yan; Shuzhen Mu; Heng Luo; Eldad Zacksenhaus; Xiaojiang Hao; Yaacov Ben-David
Journal:  Oncotarget       Date:  2017-03-07

9.  Stratification and therapeutic potential of PML in metastatic breast cancer.

Authors:  Natalia Martín-Martín; Marco Piva; Jelena Urosevic; Paula Aldaz; James D Sutherland; Sonia Fernández-Ruiz; Leire Arreal; Verónica Torrano; Ana R Cortazar; Evarist Planet; Marc Guiu; Nina Radosevic-Robin; Stephane Garcia; Iratxe Macías; Fernando Salvador; Giacomo Domenici; Oscar M Rueda; Amaia Zabala-Letona; Amaia Arruabarrena-Aristorena; Patricia Zúñiga-García; Alfredo Caro-Maldonado; Lorea Valcárcel-Jiménez; Pilar Sánchez-Mosquera; Marta Varela-Rey; Maria Luz Martínez-Chantar; Juan Anguita; Yasir H Ibrahim; Maurizio Scaltriti; Charles H Lawrie; Ana M Aransay; Juan L Iovanna; Jose Baselga; Carlos Caldas; Rosa Barrio; Violeta Serra; Maria dM Vivanco; Ander Matheu; Roger R Gomis; Arkaitz Carracedo
Journal:  Nat Commun       Date:  2016-08-24       Impact factor: 14.919

10.  Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism.

Authors:  Mahya Mehrmohamadi; Lucas K Mentch; Andrew G Clark; Jason W Locasale
Journal:  Nat Commun       Date:  2016-12-14       Impact factor: 14.919
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