Claire Mancia1, Véronique Loustaud-Ratti, Paul Carrier, Florian Naudet, Eric Bellissant, François Labrousse, Nicolas Pichon. 1. 1 Department of Anesthesiology, Dupuytren Teaching Hospital, Limoges, France. 2 Department of Hepatology, Dupuytren Teaching Hospital, Limoges, France. 3 Medical University of Limoges, Limoges, France. 4 INSERM UMR 1092, Limoges, France. 5 Clinical Investigation Center, INSERM 0203, Pontchaillou Teaching Hospital, Rennes, France. 6 Department of Clinical Pharmacology, Teaching Hospital of Rennes, Rennes, France. 7 Department of Pathology, Dupuytren Teaching Hospital, Limoges, France. 8 Department of Critical Care, Dupuytren Teaching Hospital, Limoges, France. 9 Coordination Hospitalière des Prélèvements d'Organes et de Tissus, Dupuytren Teaching Hospital, Limoges, France.
Abstract
BACKGROUND: One of the main selection criteria of the quality of a liver graft is the degree of steatosis, which will determine the success of the transplantation. The aim of this study was to evaluate the ability of FibroScan and its related methods Controlled Attenuation Parameter and Liver Stiffness to assess objectively steatosis and fibrosis in livers from brain-dead donors to be potentially used for transplantation. METHODS: Over a period of 10 months, 23 consecutive brain dead donors screened for liver procurement underwent a FibroScan and a liver biopsy. RESULTS: The different predictive models of liver retrievability using liver biopsy as the gold standard have led to the following area under receiver operating characteristic curve: 76.6% (95% confidence intervals [95% CIs], 48.2%-100%) when based solely on controlled attenuation parameter, 75.0% (95% CIs, 34.3%-100%) when based solely on liver stiffness, and 96.7% (95% CIs, 88.7%-100%) when based on combined indices. CONCLUSIONS: Our study suggests that a preoperative selection of brain-dead donors based on a combination of both Controlled Attenuation Parameter and Liver Stiffness obtained with FibroScan could result in a good preoperative prediction of the histological status and degree of steatosis of a potential liver graft.
BACKGROUND: One of the main selection criteria of the quality of a liver graft is the degree of steatosis, which will determine the success of the transplantation. The aim of this study was to evaluate the ability of FibroScan and its related methods Controlled Attenuation Parameter and Liver Stiffness to assess objectively steatosis and fibrosis in livers from brain-dead donors to be potentially used for transplantation. METHODS: Over a period of 10 months, 23 consecutive brain dead donors screened for liver procurement underwent a FibroScan and a liver biopsy. RESULTS: The different predictive models of liver retrievability using liver biopsy as the gold standard have led to the following area under receiver operating characteristic curve: 76.6% (95% confidence intervals [95% CIs], 48.2%-100%) when based solely on controlled attenuation parameter, 75.0% (95% CIs, 34.3%-100%) when based solely on liver stiffness, and 96.7% (95% CIs, 88.7%-100%) when based on combined indices. CONCLUSIONS: Our study suggests that a preoperative selection of brain-dead donors based on a combination of both Controlled Attenuation Parameter and Liver Stiffness obtained with FibroScan could result in a good preoperative prediction of the histological status and degree of steatosis of a potential liver graft.
Authors: Sara Moccia; Leonardo S Mattos; Ilaria Patrini; Michela Ruperti; Nicolas Poté; Federica Dondero; François Cauchy; Ailton Sepulveda; Olivier Soubrane; Elena De Momi; Alberto Diaspro; Manuela Cesaretti Journal: Int J Comput Assist Radiol Surg Date: 2018-05-23 Impact factor: 2.924
Authors: Ivana Mikolasevic; Tajana Filipec-Kanizaj; Maja Mijic; Ivan Jakopcic; Sandra Milic; Irena Hrstic; Nikola Sobocan; Davor Stimac; Patrizia Burra Journal: World J Gastroenterol Date: 2018-04-14 Impact factor: 5.742
Authors: Ivana Mikolasevic; Sanja Stojsavljevic; Filip Blazic; Maja Mijic; Delfa Radic-Kristo; Toni Juric; Nadija Skenderevic; Mia Klapan; Andjela Lukic; Tajana Filipec Kanizaj Journal: World J Transplant Date: 2021-03-18