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Literature DB >> 2571667

Insertion/deletion-related polymorphisms in the human T cell receptor beta gene complex.

E Seboun¹, M A Robinson, T J Kindt, S L Hauser.

Abstract

Insertion/deletion related polymorphisms (IDRP) involving stretches of 15-30 kb within the human TCR-beta gene complex were revealed by pulse-field gel electrophoresis. Two independent IDRP systems were detected by analysis of Sfi I- and Sal I-digested human DNA samples using probes for TCR C and V region gene segments. The allelic nature of these systems was verified in family studies, and mapping data allowed localization of one area of insertion/deletion among the V gene segments and the other near the C region genes. All but one of 50 individuals tested could be typed for the two allelic systems, and gene frequencies for the two allelic forms were 0.37/0.61 and 0.46/0.54, indicating that these polymorphisms are widespread.

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Year: 1989 PMID： 2571667 PMCID： PMC2189474 DOI： 10.1084/jem.170.4.1263

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

18 in total

1. Diversity and structure of human T-cell receptor beta-chain variable region genes.

Authors: P Concannon; L A Pickering; P Kung; L Hood
Journal: Proc Natl Acad Sci U S A Date: 1986-09 Impact factor: 11.205

Review 2. Genes of the T-cell antigen receptor in normal and malignant T cells.

Authors: B Toyonaga; T W Mak
Journal: Annu Rev Immunol Date: 1987 Impact factor: 28.527

3. Structure and diversity of the human T-cell receptor beta-chain variable region genes.

Authors: J P Tillinghast; M A Behlke; D Y Loh
Journal: Science Date: 1986-08-22 Impact factor: 47.728

4. Rearrangement and expression of T-cell antigen receptor genes in human T-lymphocyte tumor lines and normal human T-cell clones: evidence for allelic exclusion of Ti beta gene expression and preferential use of a J beta 2 gene segment.

Authors: J M Leiden; D P Dialynas; A D Duby; C Murre; J Seidman; J L Strominger
Journal: Mol Cell Biol Date: 1986-09 Impact factor: 4.272

5. Low frequency of somatic mutation in beta-chain variable region genes of human T-cell receptors.

Authors: K Ikuta; T Ogura; A Shimizu; T Honjo
Journal: Proc Natl Acad Sci U S A Date: 1985-11 Impact factor: 11.205

6. Generation of diversity of the beta chain of the human T-lymphocyte receptor for antigen.

Authors: J M Leiden; J L Strominger
Journal: Proc Natl Acad Sci U S A Date: 1986-06 Impact factor: 11.205

7. Murine T-cell receptor mutants with deletions of beta-chain variable region genes.

Authors: M A Behlke; H S Chou; K Huppi; D Y Loh
Journal: Proc Natl Acad Sci U S A Date: 1986-02 Impact factor: 11.205

8. Molecular genotyping of human T-cell antigen receptor variable gene segments.

Authors: M A Robinson; T J Kindt
Journal: Immunogenetics Date: 1986 Impact factor: 2.846

9. Analysis of a human V beta gene subfamily.

Authors: G Siu; E C Strauss; E Lai; L E Hood
Journal: J Exp Med Date: 1986-11-01 Impact factor: 14.307

10. Human T cell receptor V beta gene polymorphism.

Authors: P Concannon; R A Gatti; L E Hood
Journal: J Exp Med Date: 1987-04-01 Impact factor: 14.307

17 in total

1. Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locus.

Authors: L Subrahmanyan; M A Eberle; A G Clark; L Kruglyak; D A Nickerson
Journal: Am J Hum Genet Date: 2001-06-29 Impact factor: 11.025

2. Allelic sequence variations in the hypervariable region of a T-cell receptor beta chain: correlation with restriction fragment length polymorphism in human families and populations.

Authors: M A Robinson
Journal: Proc Natl Acad Sci U S A Date: 1989-12 Impact factor: 11.205

10. Novel procedures for high-throughput analysis of a frequent insertion-deletion polymorphism in the human T-cell receptor beta locus.

Authors: Bernard Conrad
Journal: Immunogenetics Date: 2004-05-25 Impact factor: 2.846

Insertion/deletion-related polymorphisms in the human T cell receptor beta gene complex.

1. Diversity and structure of human T-cell receptor beta-chain variable region genes.

Review 2. Genes of the T-cell antigen receptor in normal and malignant T cells.

3. Structure and diversity of the human T-cell receptor beta-chain variable region genes.

4. Rearrangement and expression of T-cell antigen receptor genes in human T-lymphocyte tumor lines and normal human T-cell clones: evidence for allelic exclusion of Ti beta gene expression and preferential use of a J beta 2 gene segment.

5. Low frequency of somatic mutation in beta-chain variable region genes of human T-cell receptors.

6. Generation of diversity of the beta chain of the human T-lymphocyte receptor for antigen.

7. Murine T-cell receptor mutants with deletions of beta-chain variable region genes.

8. Molecular genotyping of human T-cell antigen receptor variable gene segments.

9. Analysis of a human V beta gene subfamily.

10. Human T cell receptor V beta gene polymorphism.

1. Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locus.

2. Allelic sequence variations in the hypervariable region of a T-cell receptor beta chain: correlation with restriction fragment length polymorphism in human families and populations.

3. The extent of the human germline T-cell receptor V beta gene segment repertoire.

4. Unusual organization of the human T-cell receptor beta-chain gene complex is linked to recombination hotspots.

5. Physical mapping of the human T-cell receptor beta gene complex, using yeast artificial chromosomes.

6. The human T-cell receptor beta-chain repertoire: longitudinal fluctuations and assessment in MHC matched populations.

7. Haplotypic origin of beta-chain genes expressed by human T-cell clones.

8. Structural analysis of the mouse T-cell receptor Tcra V2 subfamily.

9. Organization of human T-cell receptor beta-chain genes: clusters of V beta genes are present on chromosomes 7 and 9.

10. Novel procedures for high-throughput analysis of a frequent insertion-deletion polymorphism in the human T-cell receptor beta locus.