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Literature DB >> 8099448

Unusual organization of the human T-cell receptor beta-chain gene complex is linked to recombination hotspots.

E Seboun¹, L Houghton, C J Hatem, R Lincoln, S L Hauser.

Abstract

Two rare Sfi I polymorphisms of 360 kb and 280 kb present within the human T-cell antigen receptor beta-chain gene complex were revealed by pulsed-field gel electrophoresis. They represent allelic variants of the polymorphic 330- and 300-kb Sfi I fragments previously described. The 360-kb polymorphism results from duplication of the 30-kb DNA fragment responsible for the 330/300-kb insertion/deletion-related polymorphism. The 280-kb polymorphism results from a 20-kb deletion from the 300-kb SfiI allele. The rare polymorphisms also map on either side of a Sal I site located near a recombination hotspot, suggesting that germline duplications and deletions arose from nonhomologous crossover events.

Entities: Chemical Species

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Year: 1993 PMID： 8099448 PMCID： PMC46646 DOI： 10.1073/pnas.90.11.5026

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

15 in total

1. Haplotyping the human T-cell receptor beta-chain gene complex by use of restriction fragment length polymorphisms.

Authors: P Charmley; A Chao; P Concannon; L Hood; R A Gatti
Journal: Proc Natl Acad Sci U S A Date: 1990-06 Impact factor: 11.205

2. Conserved organization of the human and murine T-cell receptor beta-gene families.

Authors: E Lai; P Concannon; L Hood
Journal: Nature Date: 1988-02-11 Impact factor: 49.962

Review 3. The evolution of multigene families: human haptoglobin genes.

Authors: N Maeda; O Smithies
Journal: Annu Rev Genet Date: 1986 Impact factor: 16.830

Review 4. Allelic variations of human TCR V gene products.

Authors: D N Posnett
Journal: Immunol Today Date: 1990-10

5. The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene.

Authors: G Siu; S P Clark; Y Yoshikai; M Malissen; Y Yanagi; E Strauss; T W Mak; L Hood
Journal: Cell Date: 1984-06 Impact factor: 41.582

2. A genetically determined insertion/deletion related polymorphism in human T cell receptor beta chain (TCRB) includes functional variable gene segments.

Authors: T M Zhao; S E Whitaker; M A Robinson
Journal: J Exp Med Date: 1994-10-01 Impact factor: 14.307

2 in total

Unusual organization of the human T-cell receptor beta-chain gene complex is linked to recombination hotspots.

1. Haplotyping the human T-cell receptor beta-chain gene complex by use of restriction fragment length polymorphisms.

2. Conserved organization of the human and murine T-cell receptor beta-gene families.

Review 3. The evolution of multigene families: human haptoglobin genes.

Review 4. Allelic variations of human TCR V gene products.

5. The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene.

6. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

7. Haplotypic origin of beta-chain genes expressed by human T-cell clones.

8. Molecular genotyping of human T-cell antigen receptor variable gene segments.

9. Extensive deletions and insertions in different MHC supratypes detected by pusled field gel electrophoresis.

10. Human T cell receptor V beta gene polymorphism.

1. Physical mapping of the human T-cell receptor beta gene complex, using yeast artificial chromosomes.

2. A genetically determined insertion/deletion related polymorphism in human T cell receptor beta chain (TCRB) includes functional variable gene segments.