Literature DB >> 25716548

Light-cleavable rapamycin dimer as an optical trigger for protein dimerization.

Kalyn A Brown1, Yan Zou, David Shirvanyants, Jie Zhang, Subhas Samanta, Pavan K Mantravadi, Nikolay V Dokholyan, Alexander Deiters.   

Abstract

Rapamycin-induced protein heterodimerization of FKBP12 and FRB is one of the most commonly employed switches to conditionally control biological processes. We developed an optically activated rapamycin dimer that does not induce FKBP12-FRB dimerization until exposed to light, and applied it to control kinase, protease, and recombinase function.

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Year:  2015        PMID： 25716548     DOI： 10.1039/c4cc09442e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  17 in total

Review 1.  Integrative systems and synthetic biology of cell-matrix adhesion sites.

Authors:  Eli Zamir
Journal:  Cell Adh Migr       Date:  2016-02-06       Impact factor: 3.405

2.  Controlling the Oligomerization State of Aβ-Derived Peptides with Light.

Authors:  Patrick J Salveson; Sepehr Haerianardakani; Alexander Thuy-Boun; Adam G Kreutzer; James S Nowick
Journal:  J Am Chem Soc       Date:  2018-04-20       Impact factor: 15.419

3.  A photoactivatable Cre-loxP recombination system for optogenetic genome engineering.

Authors:  Fuun Kawano; Risako Okazaki; Masayuki Yazawa; Moritoshi Sato
Journal:  Nat Chem Biol       Date:  2016-10-10       Impact factor: 15.040

Review 4.  Optochemical Control of Biological Processes in Cells and Animals.

Authors:  Nicholas Ankenbruck; Taylor Courtney; Yuta Naro; Alexander Deiters
Journal:  Angew Chem Int Ed Engl       Date:  2018-02-01       Impact factor: 15.336

5.  Reversible Control of Protein Localization in Living Cells Using a Photocaged-Photocleavable Chemical Dimerizer.

Authors:  Chanat Aonbangkhen; Huaiying Zhang; Daniel Z Wu; Michael A Lampson; David M Chenoweth
Journal:  J Am Chem Soc       Date:  2018-09-14       Impact factor: 15.419

6.  Optochemical Control of Protein Localization and Activity within Cell-like Compartments.

Authors:  Reese M Caldwell; Jessica G Bermudez; David Thai; Chanat Aonbangkhen; Benjamin S Schuster; Taylor Courtney; Alexander Deiters; Daniel A Hammer; David M Chenoweth; Matthew C Good
Journal:  Biochemistry       Date:  2018-04-19       Impact factor: 3.162

7.  Homodimeric Protein-Polymer Conjugates via the Tetrazine-trans-Cyclooctene Ligation.

Authors:  Maltish M Lorenzo; Caitlin G Decker; Muhammet U Kahveci; Samantha J Paluck; Heather D Maynard
Journal:  Macromolecules       Date:  2015-12-23       Impact factor: 5.985

8.  Self-Reporting Chemically Induced Protein Proximity System Based on a Malachite Green Derivative and the L5** Fluorogen Activating Protein.

Authors:  Guihua Zeng; Yi Wang; Marcel P Bruchez; Fu-Sen Liang
Journal:  Bioconjug Chem       Date:  2018-08-20       Impact factor: 4.774

Review 9.  Synthesis and biological evaluation of rapamycin-derived, next generation small molecules.

Authors:  Shiva Krishna Reddy Guduru; Prabhat Arya
Journal:  Medchemcomm       Date:  2017-11-22       Impact factor: 3.597

10.  Genetically encoded optical activation of DNA recombination in human cells.

Authors:  J Luo; E Arbely; J Zhang; C Chou; R Uprety; J W Chin; A Deiters
Journal:  Chem Commun (Camb)       Date:  2016-06-30       Impact factor: 6.222
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