Literature DB >> 2571580

Linkage analysis in familial adenomatous polyposis: order of C11P11 (D5S71) and pi 227 (D5S37) loci at the apc gene.

M G Dunlop1, C M Steel, A H Wyllie, C C Bird, H J Evans.   

Abstract

Linkage analysis with DNA probes C11P11 and pi 227 is reported in six Scottish families with familial adenomatous polyposis. Two families were informative for C11P11 and all six were at least partly informative for pi 227. Two C11P11-apc and two pi 227-apc recombinants were identified and one of these was recombinant for both C11P11-apc and pi 227-apc. A further possible combined C11P11-apc and pi 227-apc recombination event was also identified. Peak lod score for linkage of C11P11 to apc was 5.80 at a recombination fraction (theta) of 0.069 (95% probability limits 0.012-0.191) and for linkage of pi 227 to apc was 3.19 at theta = 0.110 (95% probability limits 0.023-0.286). Peak lod score for linkage of C11P11 to pi 227 was 1.79 at theta = 0.00. The data support a gene order of pi 227-C11P11-apc.

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Year:  1989        PMID： 2571580     DOI： 10.1016/0888-7543(89)90068-2

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  6 in total

1.  Probe KK5.33 (D5S85) improves indirect genotype analysis in familial adenomatous polyposis.

Authors:  W Friedl; A Krömer; P Propping
Journal:  Hum Genet       Date:  1991-02       Impact factor: 4.132

2.  A new deletion polymorphism at D5S71 raises the linkage information on adenomatous polyposis coli: implications for presymptomatic diagnosis.

Authors:  C M Tops; C Breukel; H M van der Klift; I S von Leeuwen; J T Wijnen; G Griffioen; H F Vasen; F C den Hartog Jager; F M Nagengast; C B Lamers
Journal:  Hum Genet       Date:  1991-02       Impact factor: 4.132

3.  Linkage analysis in adenomatous polyposis coli: the use of four closely linked DNA probes in 20 UK families.

Authors:  M B Cachon-Gonzalez; J D Delhanty; J Burn; K Tsioupra; M B Davis; J Attwood; P Chapman
Journal:  J Med Genet       Date:  1991-10       Impact factor: 6.318

4.  The UK Northern region genetic register for familial adenomatous polyposis coli: use of age of onset, congenital hypertrophy of the retinal pigment epithelium, and DNA markers in risk calculations.

Authors:  J Burn; P Chapman; J Delhanty; C Wood; F Lalloo; M B Cachon-Gonzalez; K Tsioupra; W Church; M Rhodes; A Gunn
Journal:  J Med Genet       Date:  1991-05       Impact factor: 6.318

5.  Genetic linkage map of six polymorphic DNA markers around the gene for familial adenomatous polyposis on chromosome 5.

Authors:  M G Dunlop; A H Wyllie; Y Nakamura; C M Steel; H J Evans; R L White; C C Bird
Journal:  Am J Hum Genet       Date:  1990-12       Impact factor: 11.025

6.  Stability of critical genetic lesions in human colorectal carcinoma xenografts.

Authors:  H A McQueen; A H Wyllie; J Piris; E Foster; C C Bird
Journal:  Br J Cancer       Date:  1991-01       Impact factor: 7.640
  6 in total

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