Literature DB >> 1658324

Linkage analysis in adenomatous polyposis coli: the use of four closely linked DNA probes in 20 UK families.

M B Cachon-Gonzalez1, J D Delhanty, J Burn, K Tsioupra, M B Davis, J Attwood, P Chapman.   

Abstract

Linkage analysis was carried out on 20 unselected UK families segregating for adenomatous polyposis coli (APC) using four closely linked DNA probes. Significant lod scores were obtained between APC and three markers: pi 227 (D5S37) theta = 0.16; C11p11 (D5S71) theta = 0.10; and YN5.48 (D5S81) theta = 0.00. The fourth, ECB27 (D5S98), gave low lod scores. The APC gene showed linkage with at least one of the probes used in all families, which is in agreement with previous publications. Combined lod scores are now sufficiently high to allow the use of these probes in presymptomatic diagnosis. Despite the fact that 61% of persons at risk were informative for at least one DNA marker, only 15% were informative with flanking probes. One prenatal diagnosis was performed where the initial request had been for sterilisation.

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Year:  1991        PMID： 1658324      PMCID： PMC1017054          DOI： 10.1136/jmg.28.10.681

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  20 in total

1.  A genetic and clinical study of intestinal polyposis, a predisposing factor for carcinoma of the colon and rectum.

Authors:  E J GARDNER
Journal:  Am J Hum Genet       Date:  1951-06       Impact factor: 11.025

2.  Ozone and Acid rain.

Authors:  P H Abelson
Journal:  Science       Date:  1987-10-09       Impact factor: 47.728

3.  Linkage analysis in familial adenomatous polyposis: order of C11P11 (D5S71) and pi 227 (D5S37) loci at the apc gene.

Authors:  M G Dunlop; C M Steel; A H Wyllie; C C Bird; H J Evans
Journal:  Genomics       Date:  1989-08       Impact factor: 5.736

4.  A computer program to make linkage analysis with LIPED and LINKAGE easier to perform and less prone to input errors.

Authors:  J Attwood; S Bryant
Journal:  Ann Hum Genet       Date:  1988-07       Impact factor: 1.670

5.  An anonymous DNA segment (II227) maps to the long arm of human chromosome 5 and identifies a BstXI polymorphism (D5S26).

Authors:  G D Stewart; G A Bruns; J J Wasmuth; D M Kurnit
Journal:  Nucleic Acids Res       Date:  1987-05-11       Impact factor: 16.971

6.  Localization of the gene for familial adenomatous polyposis on chromosome 5.

Authors:  W F Bodmer; C J Bailey; J Bodmer; H J Bussey; A Ellis; P Gorman; F C Lucibello; V A Murday; S H Rider; P Scambler
Journal:  Nature       Date:  1987 Aug 13-19       Impact factor: 49.962

7.  The evolution of cancer of the colon and rectum.

Authors:  T Muto; H J Bussey; B C Morson
Journal:  Cancer       Date:  1975-12       Impact factor: 6.860

8.  The UK Northern region genetic register for familial adenomatous polyposis coli: use of age of onset, congenital hypertrophy of the retinal pigment epithelium, and DNA markers in risk calculations.

Authors:  J Burn; P Chapman; J Delhanty; C Wood; F Lalloo; M B Cachon-Gonzalez; K Tsioupra; W Church; M Rhodes; A Gunn
Journal:  J Med Genet       Date:  1991-05       Impact factor: 6.318

9.  Close linkage of a highly polymorphic marker (D5S37) to familial adenomatous polyposis (FAP) and confirmation of FAP localization on chromosome 5q21-q22.

Authors:  P Meera Khan; C M Tops; M vd Broek; C Breukel; J T Wijnen; M Oldenburg; J vd Bos; I S van Leeuwen-Cornelisse; H F Vasen; G Griffioen
Journal:  Hum Genet       Date:  1988-06       Impact factor: 4.132

10.  Genetic linkage map of six polymorphic DNA markers around the gene for familial adenomatous polyposis on chromosome 5.

Authors:  M G Dunlop; A H Wyllie; Y Nakamura; C M Steel; H J Evans; R L White; C C Bird
Journal:  Am J Hum Genet       Date:  1990-12       Impact factor: 11.025
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  5 in total

1.  A clinical and genetic database for management of familial adenomatous polyposis.

Authors:  I Fenton; J Sampson
Journal:  J Med Genet       Date:  1992-08       Impact factor: 6.318

2.  Linkage studies in Italian families with familial adenomatous polyposis.

Authors:  C Mareni; A Stella; P Origone; F Susca; M P Montera; A Lonoce; M Ponz de Leon; R Sassatelli; M Gentile; A Straface
Journal:  Hum Genet       Date:  1993-01       Impact factor: 4.132

3.  Enhanced intestinal tumor multiplicity and grade in vivo after HZE exposure: mouse models for space radiation risk estimates.

Authors:  Daniela Trani; Kamal Datta; Kathryn Doiron; Bhaskar Kallakury; Albert J Fornace
Journal:  Radiat Environ Biophys       Date:  2010-05-20       Impact factor: 1.925

4.  Evaluation of molecular genetic diagnosis in the management of familial adenomatous polyposis coli: a population based study.

Authors:  E R Maher; D E Barton; R Slatter; D J Koch; M H Jones; H Nagase; S J Payne; S J Charles; A T Moore; Y Nakamura
Journal:  J Med Genet       Date:  1993-08       Impact factor: 6.318

5.  Presymptomatic diagnosis in families with adenomatous polyposis using highly polymorphic dinucleotide CA repeat markers flanking the APC gene.

Authors:  W A Eckert; C Jung; G Wolff
Journal:  J Med Genet       Date:  1994-06       Impact factor: 6.318
  5 in total

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