Literature DB >> 2571571

Localization of a human brain sodium channel gene (SCN2A) to chromosome 2.

M Litt1, J Luty, M Kwak, L Allen, R E Magenis, G Mandel.   

Abstract

A DNA probe derived from a human genomic library has been used to localize on human chromosomes a gene coding for the alpha-subunit of the brain type II sodium channel (SCN2A). Hybridization of the probe to Southern blots made with DNAs from a rodent-human somatic cell hybrid panel indicates localization to the long arm of human chromosome 2. In situ hybridization to metaphase chromosomes confirms this assignment and indicates regional localization to 2q21-q33. The probe also reveals a frequent two-allele HaeIII RFLP.

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Year:  1989        PMID： 2571571     DOI： 10.1016/0888-7543(89)90047-5

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  12 in total

1.  Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain.

Authors:  C M Ahmed; D H Ware; S C Lee; C D Patten; A V Ferrer-Montiel; A F Schinder; J D McPherson; C B Wagner-McPherson; J J Wasmuth; G A Evans
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-01       Impact factor: 11.205

Review 2.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

3.  Use-dependent potentiation of the Nav1.6 sodium channel.

Authors:  W Zhou; A L Goldin
Journal:  Biophys J       Date:  2004-10-01       Impact factor: 4.033

4.  Direct amplification of a single dissected chromosomal segment by polymerase chain reaction: a human brain sodium channel gene is on chromosome 2q22-q23.

Authors:  J A Han; C M Lu; G B Brown; T A Rado
Journal:  Proc Natl Acad Sci U S A       Date:  1991-01-15       Impact factor: 11.205

5.  Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel.

Authors:  M E Gellens; A L George; L Q Chen; M Chahine; R Horn; R L Barchi; R G Kallen
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-15       Impact factor: 11.205

6.  Paroxysmal dystonic choreoathetosis: tight linkage to chromosome 2q.

Authors:  J K Fink; S Rainer; J Wilkowski; S M Jones; A Kume; P Hedera; R Albin; J Mathay; L Girbach; T Varvil; B Otterud; M Leppert
Journal:  Am J Hum Genet       Date:  1996-07       Impact factor: 11.025

Review 7.  Structure, function and expression of voltage-dependent sodium channels.

Authors:  R G Kallen; S A Cohen; R L Barchi
Journal:  Mol Neurobiol       Date:  1993 Fall-Winter       Impact factor: 5.590

8.  Targeted gene walking by low stringency polymerase chain reaction: assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31.

Authors:  M S Malo; K Srivastava; J M Andresen; X N Chen; J R Korenberg; V M Ingram
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-12       Impact factor: 11.205

9.  The alpha-subunit of the skeletal muscle sodium channel is encoded proximal to Tk-1 on mouse chromosome 11.

Authors:  C Ambrose; S Cheng; B Fontaine; J H Nadeau; M MacDonald; J F Gusella
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

10.  Analysis in a large hyperkalemic periodic paralysis pedigree supports tight linkage to a sodium channel locus.

Authors:  L J Ptacek; F Tyler; J S Trimmer; W S Agnew; M Leppert
Journal:  Am J Hum Genet       Date:  1991-08       Impact factor: 11.025
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