Josefine Nasiell1, Nikos Papadogiannakis2,3, Erika Löf1, Fanny Elofsson1, Boubou Hallberg4. 1. a Department of Obstetrics & Gynaecology , Karolinska University Hospital , Stockholm , Sweden . 2. b Department of Laboratory Medicine, Division of Pathology , Section of Perinatal Pathology, Karolinska Institute , Stockholm , Sweden . 3. c Karolinska University Hospital , Stockholm , Sweden , and. 4. d Department of Neonatalogy , Karolinska University Hospital , Stockholm , Sweden.
Abstract
OBJECTIVE: Birth asphyxia and hypoxic ischemic encephalopathy (HIE) of the newborn remain serious complications. We present a study investigating if placental or umbilical cord abnormalities in newborns at term are associated with HIE. MATERIALS AND METHODS: A prospective cohort study of the placenta and umbilical cord of infants treated with hypothermia (HT) due to hypoxic brain injury and follow-up at 12 months of age has been carried out. The study population included 41 infants treated for HT whose placentas were submitted for histopathological analysis. Main outcome measures were infant development at 12 months, classified as normal, cerebral palsy, or death. A healthy group of 100 infants without HIE and normal follow-up at 12 months of age were used as controls. RESULTS: A velamentous or marginal umbilical cord insertion and histological abruption was associated with the risk of severe HIE, OR = 5.63, p = 0.006, respectively, OR = 20.3, p = 0.01 (multiple-logistic regression). Velamentous or marginal umbilical cord insertion was found in 39% among HIE cases compared to 7% in controls. CONCLUSIONS: Placental and umbilical cord abnormalities have a profound association with HIE. A prompt examination of the placentas of newborns suffering from asphyxia can provide important information on the pathogenesis behind the incident and contribute to make a better early prognosis.
OBJECTIVE:Birth asphyxia and hypoxic ischemicencephalopathy (HIE) of the newborn remain serious complications. We present a study investigating if placental or umbilical cord abnormalities in newborns at term are associated with HIE. MATERIALS AND METHODS: A prospective cohort study of the placenta and umbilical cord of infants treated with hypothermia (HT) due to hypoxic brain injury and follow-up at 12 months of age has been carried out. The study population included 41 infants treated for HT whose placentas were submitted for histopathological analysis. Main outcome measures were infant development at 12 months, classified as normal, cerebral palsy, or death. A healthy group of 100 infants without HIE and normal follow-up at 12 months of age were used as controls. RESULTS: A velamentous or marginal umbilical cord insertion and histological abruption was associated with the risk of severe HIE, OR = 5.63, p = 0.006, respectively, OR = 20.3, p = 0.01 (multiple-logistic regression). Velamentous or marginal umbilical cord insertion was found in 39% among HIE cases compared to 7% in controls. CONCLUSIONS: Placental and umbilical cord abnormalities have a profound association with HIE. A prompt examination of the placentas of newborns suffering from asphyxia can provide important information on the pathogenesis behind the incident and contribute to make a better early prognosis.
Authors: Mercedes Olaya-C; Marta Garrido; Javier Hernandez-Losa; Marta Sesé; Paola Ayala-Ramirez; Rosa Somoza; Magda Jimena Vargas; Santiago Ramón Y Cajal Journal: Int J Womens Health Date: 2018-11-28
Authors: Szabolcs Zahorán; Péter R Szántó; Nikolett Bódi; Mária Bagyánszki; József Maléth; Péter Hegyi; Tamás Sári; Edit Hermesz Journal: Antioxidants (Basel) Date: 2021-04-09
Authors: Jessica L Wisnowski; Stefan Bluml; Ashok Panigrahy; Amit M Mathur; Jeffrey Berman; Ping-Sun Keven Chen; James Dix; Trevor Flynn; Stanley Fricke; Seth D Friedman; Hayden W Head; Chang Y Ho; Beth Kline-Fath; Michael Oveson; Richard Patterson; Sumit Pruthi; Nancy Rollins; Yanerys M Ramos; John Rampton; Jerome Rusin; Dennis W Shaw; Mark Smith; Jean Tkach; Shreyas Vasanawala; Arastoo Vossough; Matthew T Whitehead; Duan Xu; Kristen Yeom; Bryan Comstock; Patrick J Heagerty; Sandra E Juul; Yvonne W Wu; Robert C McKinstry Journal: BMJ Open Date: 2021-04-22 Impact factor: 2.692