| Literature DB >> 25713288 |
Jörg Hamann1, Gabriela Aust1, Demet Araç1, Felix B Engel1, Caroline Formstone1, Robert Fredriksson1, Randy A Hall1, Breanne L Harty1, Christiane Kirchhoff1, Barbara Knapp1, Arunkumar Krishnan1, Ines Liebscher1, Hsi-Hsien Lin1, David C Martinelli1, Kelly R Monk1, Miriam C Peeters1, Xianhua Piao1, Simone Prömel1, Torsten Schöneberg1, Thue W Schwartz1, Kathleen Singer1, Martin Stacey1, Yuri A Ushkaryov1, Mario Vallon1, Uwe Wolfrum1, Mathew W Wright1, Lei Xu1, Tobias Langenhan1, Helgi B Schiöth1.
Abstract
The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.Entities:
Mesh：
Substances：
Year: 2015 PMID： 25713288 PMCID： PMC4394687 DOI： 10.1124/pr.114.009647
Source DB: PubMed Journal: Pharmacol Rev ISSN： 0031-6997 Impact factor: 25.468