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Literature DB >> 25708456

A step forward in elucidating the mystery of OCD.

Sina Kohl¹, Lena Ebbert¹, Alexander Sartorius², Jens Kuhn³.

Abstract

Obsessive-compulsive disorder represents one of the most disabling psychiatric disorders. The underlying pathophysiology is not fully understood. In a recent Science article, Ahmari and colleagues enlighten fundamental aspects of obsessive-compulsive disorder by means of optogenetic stimulation, thereby also elucidating the usefulness of SSRI in the treatment for OCD.

Entities: Disease

Keywords: Deep brain stimulation; Obsessive compulsive disorder; Optogenetic stimulation

Mesh：

Year: 2015 PMID： 25708456 DOI： 10.1007/s00406-015-0584-2

Source DB: PubMed Journal: Eur Arch Psychiatry Clin Neurosci ISSN： 0940-1334 Impact factor: 5.270

10 in total

1. Global and local fMRI signals driven by neurons defined optogenetically by type and wiring.

Authors: Jin Hyung Lee; Remy Durand; Viviana Gradinaru; Feng Zhang; Inbal Goshen; Dae-Shik Kim; Lief E Fenno; Charu Ramakrishnan; Karl Deisseroth
Journal: Nature Date: 2010-06-10 Impact factor: 49.962

2. Evidence-based health policy--lessons from the Global Burden of Disease Study.

Authors: C J Murray; A D Lopez
Journal: Science Date: 1996-11-01 Impact factor: 47.728

3. Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder.

Authors: Martijn Figee; Judy Luigjes; Ruud Smolders; Carlos-Eduardo Valencia-Alfonso; Guido van Wingen; Bart de Kwaasteniet; Mariska Mantione; Pieter Ooms; Pelle de Koning; Nienke Vulink; Nina Levar; Lukas Droge; Pepijn van den Munckhof; P Richard Schuurman; Aart Nederveen; Wim van den Brink; Ali Mazaheri; Matthijs Vink; Damiaan Denys
Journal: Nat Neurosci Date: 2013-02-24 Impact factor: 24.884

4. Repeated cortico-striatal stimulation generates persistent OCD-like behavior.

Authors: Susanne E Ahmari; Timothy Spellman; Neria L Douglass; Mazen A Kheirbek; H Blair Simpson; Karl Deisseroth; Joshua A Gordon; René Hen
Journal: Science Date: 2013-06-07 Impact factor: 47.728

Review 5. Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive-compulsive disorder.

Authors: J G Modell; J M Mountz; G C Curtis; J F Greden
Journal: J Neuropsychiatry Clin Neurosci Date: 1989 Impact factor: 2.198

1 in total

1. Unravelling basic mechanisms in addiction and neuropsychiatric disorders.

Authors: Daniela Reich-Erkelenz; Andrea Schmitt; Peter Falkai
Journal: Eur Arch Psychiatry Clin Neurosci Date: 2015-12 Impact factor: 5.270

1 in total

A step forward in elucidating the mystery of OCD.

1. Global and local fMRI signals driven by neurons defined optogenetically by type and wiring.

2. Evidence-based health policy--lessons from the Global Burden of Disease Study.

3. Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder.

4. Repeated cortico-striatal stimulation generates persistent OCD-like behavior.

Review 5. Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive-compulsive disorder.

6. Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder.

7. Lifetime prevalence of specific psychiatric disorders in three sites.

Review 8. Network perspectives on the mechanisms of deep brain stimulation.

9. Optogenetics.

10. Deep brain stimulation for treatment-refractory obsessive compulsive disorder: a systematic review.

1. Unravelling basic mechanisms in addiction and neuropsychiatric disorders.