| Literature DB >> 25708215 |
Melissa D Docampo1, Jeffery J Auletta2, Robert R Jenq3.
Abstract
The intestinal microbiota has many critical roles in maintaining gastrointestinal epithelial and gastrointestinal systemic immune homeostasis. This review provides insight into how allogeneic hematopoietic cell transplantation (HCT) and its associated complications and supportive care therapies affect the microbiota. Additionally, the review discusses how preservation and restoration of the microbiota might be advantageous in decreasing HCT-related morbidity and mortality.Entities:
Keywords: Antimicrobial peptide; Bacteremia; Bone marrow transplant; Clostridium difficile; Dysbiosis; Enterocyte; Graft-versus-host disease; Gut microbiota; IL-22; Paneth cell; Regenerating islet-derived III alpha; T cell; Tolerance
Mesh:
Year: 2015 PMID: 25708215 DOI: 10.1016/j.bbmt.2015.02.016
Source DB: PubMed Journal: Biol Blood Marrow Transplant ISSN: 1083-8791 Impact factor: 5.742