| Literature DB >> 25706322 |
Lourdes Ortego1, Jesús Gonzalo-Asensio2, Antonio Laguna1, M Dolores Villacampa3, M Concepción Gimeno4.
Abstract
This manuscript describes the synthesis of new Au(I) and Ag(I) complexes with aminophosphane ligands and a study of their antibacterial activity against Gram-negative Salmonella enterica serovar typhimurium and Escherichia coli and Gram-positive Listeria monocytogenes and Staphylococcus aureus. The bactericidal assays revealed the effectiveness of these compounds on paradigm Gram-negative and Gram-positive pathogens, showing a moderate antimicrobial activity, comparable with the antibiotics of reference, for all gold(I) complexes and the silver(I) complexes without coordinated PPh3 groups. For those complexes that were found to show inhibitory activity, serial dilutions in liquid broth method were performed for determination of MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration).Entities:
Keywords: Aminophosphine ligands; Antibacterial activity; Gold(I); Gram-negative; Gram-positive; Silver(I)
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Year: 2015 PMID： 25706322 DOI： 10.1016/j.jinorgbio.2015.01.007
Source DB: PubMed Journal: J Inorg Biochem ISSN： 0162-0134 Impact factor: 4.155