M Reigneau1, C Robert1, E Routier1, G Mamelle2, A Moya-Plana2, G Tomasic3, C Mateus1. 1. Dermatology Unit, Department of Medical Oncology, Gustave Roussy, 114 rue Edouard Vaillant, 94800, Villejuif, France. 2. Department of Surgery, Gustave Roussy, 114 rue Edouard Vaillant, 94800, Villejuif, France. 3. Department of Pathology, Gustave Roussy, 114 rue Edouard Vaillant, 94800, Villejuif, France.
Abstract
BACKGROUND:Refractory locally advanced or metastatic nonmelanoma skin cancer (NMSC) is a frequent therapeutic impasse. OBJECTIVES: To address the question of the efficacy of induction therapy with cetuximab as neoadjuvant treatment for locally advanced NMSC. METHODS:From 2008 to 2013, all patients with a diagnosis of unresectable locally advanced skin squamous cell carcinoma were treated with neoadjuvant cetuximab alone (CM) or combined with a platinum salt and 5-fluorouracil (CC). Resectability, and clinical and pathological response, as well as relapse-free and overall survival were evaluated. RESULTS:Thirty-four patients, with a median age of 74·5 years, were evaluated. Twenty-five patients received CC. After three cycles of CC, 23 of 25 patients whose tumours were initially unresectable became amenable to surgery (92%). A complete histological response was observed in 15 (65%) patients. The mean progression-free and mean overall survival in operated patients were 8·5 and 26·0 months, respectively. CONCLUSIONS: There was a good response in terms of resectability and tumour control in the majority of patients, with few relapses, despite the initially poor prognosis of these tumours in this elderly group of patients. However, this therapeutic strategy needs to be validated in a prospective, randomized study.
RCT Entities:
BACKGROUND: Refractory locally advanced or metastatic nonmelanoma skin cancer (NMSC) is a frequent therapeutic impasse. OBJECTIVES: To address the question of the efficacy of induction therapy with cetuximab as neoadjuvant treatment for locally advanced NMSC. METHODS: From 2008 to 2013, all patients with a diagnosis of unresectable locally advanced skin squamous cell carcinoma were treated with neoadjuvant cetuximab alone (CM) or combined with a platinum salt and 5-fluorouracil (CC). Resectability, and clinical and pathological response, as well as relapse-free and overall survival were evaluated. RESULTS: Thirty-four patients, with a median age of 74·5 years, were evaluated. Twenty-five patients received CC. After three cycles of CC, 23 of 25 patients whose tumours were initially unresectable became amenable to surgery (92%). A complete histological response was observed in 15 (65%) patients. The mean progression-free and mean overall survival in operated patients were 8·5 and 26·0 months, respectively. CONCLUSIONS: There was a good response in terms of resectability and tumour control in the majority of patients, with few relapses, despite the initially poor prognosis of these tumours in this elderly group of patients. However, this therapeutic strategy needs to be validated in a prospective, randomized study.
Authors: Gino K In; Poorva Vaidya; Alexandra Filkins; David J Hermel; Kevin G King; Omar Ragab; William W Tseng; Mark Swanson; Niels Kokot; Julie E Lang; Lawrence Menendez; Brittney DeClerck; Gene Kim; Jenny C Hu; Alicia Terando; Hossein Jadvar; Charité Ricker; Kimberly A Miller; David H Peng; Ashley Wysong Journal: J Cancer Res Clin Oncol Date: 2020-11-18 Impact factor: 4.553
Authors: Andrew M Overmiller; Kathleen P McGuinn; Brett J Roberts; Felicia Cooper; Donna M Brennan-Crispi; Takahiro Deguchi; Sirkku Peltonen; James K Wahl; Mỹ G Mahoney Journal: Oncotarget Date: 2016-06-21