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Literature DB >> 34097150

Investigative Landscape in Advanced Non-Melanoma Skin Cancers.

Priyanka Reddy¹, Min Yao², Monaliben Patel³.

Abstract

OPINION STATEMENT: Advanced non-melanoma skin cancers have been challenging to treat due to limited treatment options. Treatment paradigm has shifted with the approval of immunotherapeutic agents cemiplimab and pembrolizumab which have been a key development and have changed the landscape of advanced or metastatic squamous cell skin cancers. Hedgehog inhibitors, vismodegib and sonidegib, remain upfront options for advanced or metastatic basal cell carcinomas. Current clinical trials are continuing to evaluate the use of immune checkpoint inhibitors and hedgehog pathway inhibitors. There is further need for ongoing research and development of new therapies in both malignancies.

Entities: Chemical

Keywords: Basal cell skin cancer; Cutaneous malignancy; Metastatic non-melanoma skin cancer, cemiplimab, pembrolizumab; Squamous cell skin cancer

Mesh：

Substances：

Year: 2021 PMID： 34097150 DOI： 10.1007/s11864-021-00853-0

Source DB: PubMed Journal: Curr Treat Options Oncol ISSN： 1534-6277

58 in total

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Journal: Curr Oncol Date: 2019-04-01 Impact factor: 3.677

5. Treatment patterns and cost of nonmelanoma skin cancer management.

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Journal: Dermatol Surg Date: 2006-10 Impact factor: 3.398

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Journal: J Immunother Date: 2017-01 Impact factor: 4.456

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Authors: Veronika Blum; Beat Müller; Silvia Hofer; Esther Pardo; Kristin Zeidler; Joachim Diebold; Klaus Strobel; Christoph Brand; Stefan Aebi; Oliver Gautschi
Journal: Eur J Dermatol Date: 2018-02-01 Impact factor: 3.328

8. Skin cancer is among the most costly of all cancers to treat for the Medicare population.

Authors: Tamara Salam Housman; Steven R Feldman; Phillip M Williford; Alan B Fleischer; Neal D Goldman; Jose M Acostamadiedo; G John Chen
Journal: J Am Acad Dermatol Date: 2003-03 Impact factor: 11.527

9. Definitive and Postoperative Radiation Therapy for Basal and Squamous Cell Cancers of the Skin: Executive Summary of an American Society for Radiation Oncology Clinical Practice Guideline.

Authors: Anna Likhacheva; Musaddiq Awan; Christopher A Barker; Ajay Bhatnagar; Lisa Bradfield; Mary Sue Brady; Ivan Buzurovic; Jessica L Geiger; Upendra Parvathaneni; Sandra Zaky; Phillip M Devlin
Journal: Pract Radiat Oncol Date: 2019-12-09