| Literature DB >> 25700232 |
Seong-Hwan Kim1, Yoonho Shin1, So-Hyoung Lee2, Ki-Bong Oh2, Sang Kook Lee1, Jongheon Shin1, Dong-Chan Oh1.
Abstract
Salternamides A-D (1-4), the first secondary metabolites discovered from saltern-derived actinomycetes, were isolated from a halophilic Streptomyces strain isolated from a saltern on Shinui Island in the Republic of Korea. The planar structures of the salternamides, which are new members of the manumycin family, were elucidated by a combination of spectroscopic analyses. The absolute configurations of the salternamides were determined by chemical and spectroscopic methods, including the modified Mosher's method, J-based configuration analysis, and circular dichroism spectroscopy. Salternamide A (1), which is the first chlorinated compound in the manumycin family, exhibited potent cytotoxicity against a human colon cancer cell line (HCT116) and a gastric cancer cell line (SNU638) with submicromolar IC50 values. Salternamides A and D were also determined to be weak Na(+)/K(+) ATPase inhibitors.Entities:
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Year: 2015 PMID： 25700232 DOI： 10.1021/acs.jnatprod.5b00002
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050